Erythropoetin

EPO
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BUY, 1CN4, 1EER
Identifiers
Aliases	EPO, EP, MVCD2, erythropoietin, Erythropoietin
External IDs	OMIM: 133170 MGI: 95407 HomoloGene: 624 GeneCards: EPO
Gene location (Human) Chr. Chromosome 7 (human) Band 7q22.1 Start 100,720,800 bp End 100,723,700 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band n/a Start 137,483,020 bp End 137,533,242 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • hormone activity • protein kinase activator activity • protein binding • erythropoietin receptor binding Cellular component • extracellular region • cell surface • cell body • extracellular space Biological process • erythrocyte maturation • negative regulation of cation channel activity • response to interleukin-1 • response to hypoxia • negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress • response to nutrient • response to salt stress • negative regulation of erythrocyte apoptotic process • response to testosterone • regulation of transcription from RNA polymerase II promoter • response to hyperoxia • positive regulation of Ras protein signal transduction • aging • negative regulation of apoptotic process • negative regulation of transcription from RNA polymerase II promoter • response to electrical stimulus • blood circulation • response to estrogen • cellular hyperosmotic response • positive regulation of transcription, DNA-templated • positive regulation of DNA replication • response to vitamin A • response to lipopolysaccharide • acute-phase response • peptidyl-serine phosphorylation • response to axon injury • hemoglobin biosynthetic process • positive regulation of neuron differentiation • positive regulation of cell proliferation • regulation of transcription from RNA polymerase II promoter in response to hypoxia • positive regulation of ERK1 and ERK2 cascade • positive regulation of neuron projection development • negative regulation of calcium ion transport into cytosol • negative regulation of myeloid cell apoptotic process • activation of protein kinase activity • embryo implantation • signal transduction • positive regulation of activated T cell proliferation • positive regulation of protein kinase activity • negative regulation of neuron death • apoptotic process • response to dexamethasone • cell proliferation • erythrocyte differentiation • erythropoietin-mediated signaling pathway • positive regulation of tyrosine phosphorylation of STAT protein Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2056	13856
Ensembl	ENSG00000130427	ENSMUSG00000029711
UniProt	P01588	P07321
RefSeq (mRNA)	NM_000799	NM_007942 NM_001312875
RefSeq (protein)	NP_000790	NP_001299804 NP_031968
Location (UCSC)	Chr 7: 100.72 – 100.72 Mb	Chr 7: 137.48 – 137.53 Mb
PubMed search

1BUY, 1CN4, 1EER

2056

13856

ENSG00000130427

ENSMUSG00000029711

P01588

P07321

NM_000799

NM_007942
NM_001312875

NP_000790

NP_001299804
NP_031968

Erythropoietin (EPO), also known as hematopoietin or hemopoietin, is a glycoprotein cytokine secreted by the kidney in response to cellular hypoxia; it stimulates red blood cell production (erythropoiesis) in the bone marrow. Low levels of EPO (around 10 mU/ml) are constantly secreted sufficient to compensate for normal red blood cell turnover. Common causes of cellular hypoxia resulting in elevated levels of EPO (up to 10,000 mU/ml) include any anemia, and hypoxemia due to chronic lung disease.

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