Ernst Viktor von Leyden (20 April 1832 – 5 October 1910) was a German internist from Danzig.
He studied medicine at the Friedrich-Wilhelms-Institut in Berlin, and was a pupil of Johann Lukas Schönlein (1793–1864) and Ludwig Traube (1818–1876). He was later a medical professor at the universities of Königsberg, Strassburg and Berlin. Leyden was an important influence to the career of Ludwig Edinger (1855–1918), and during his tenure at the University of Königsberg worked closely with Otto Spiegelberg (1830–1881) and Friedrich Daniel von Recklinghausen (1833–1910). Among his better known students and assistants were Hermann Nothnagel (1841–1905) at Königsberg and Hermann Ludwig Eichhorst (1849–1921) in Berlin.
In 1880, with Friedrich Theodor von Frerichs, he founded the Zeitschrift für klinische Medizin; in 1881 he founded the Gesellschaft für innere Medizin. He treated Frederick III, German Emperor for his cancer of the larynx, though unsuccessfully, and in the 1890s (from 1894) he was a physician to Czar Alexander III of Russia.
Leyden died in Berlin. The political philosopher Wolfgang von Leyden (1911-2004) was his grandson.
Leyden specialized in neurological diseases, and was also a leader in establishing proper hospital facilities for tuberculosis patients. He wrote articles on a wide array of medical topics, including works on tabes dorsalis and poliomyelitis. In 1887–99 he published the two-volume Handbuch der Ernährungstherapie (Textbook of Dietetic Therapy); second edition 1903–04.