ErbB3

ERBB3

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1M6B, 2L9U, 3KEX, 3LMG, 3P11, 4LEO, 4OTW, 4P59, 4RIW, 4RIX, 4RIY, 5CUS

Identifiers

Aliases

ERBB3, ErbB-3, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3, erb-b2 receptor tyrosine kinase 3

External IDs

MGI: 95411 HomoloGene: 20457 GeneCards: ERBB3

Genetically Related Diseases

obesity, type 1 diabetes mellitus

Gene ontology
Molecular function	• transferase activity • nucleotide binding • protein kinase activity • protein tyrosine kinase activator activity • growth factor binding • protein homodimerization activity • kinase activity • protein binding • identical protein binding • protein heterodimerization activity • ATP binding • transmembrane signaling receptor activity • neuregulin binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • Ras guanyl-nucleotide exchange factor activity • protein tyrosine kinase activity
Cellular component	• integral component of membrane • lateral plasma membrane • membrane • plasma membrane • integral component of plasma membrane • extracellular region • basolateral plasma membrane • apical plasma membrane • intracellular • receptor complex • extracellular space
Biological process	• neuron apoptotic process • negative regulation of cell adhesion • phosphorylation • endocardial cushion development • positive regulation of protein tyrosine kinase activity • wound healing • MAPK cascade • positive regulation of calcineurin-NFAT signaling cascade • heart development • protein phosphorylation • negative regulation of secretion • regulation of cell proliferation • extrinsic apoptotic signaling pathway in absence of ligand • phosphatidylinositol 3-kinase signaling • positive regulation of phosphatidylinositol 3-kinase signaling • negative regulation of signal transduction • phosphatidylinositol-mediated signaling • signal transduction • cranial nerve development • regulation of phosphatidylinositol 3-kinase signaling • negative regulation of neuron apoptotic process • positive regulation of GTPase activity • Schwann cell differentiation • phosphatidylinositol phosphorylation • regulation of cell motility • peripheral nervous system development • transmembrane receptor protein tyrosine kinase signaling pathway • ERBB2 signaling pathway • peptidyl-tyrosine phosphorylation • positive regulation of cardiac muscle tissue development • positive regulation of gene expression • negative regulation of ERBB signaling pathway
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


2065


13867

Ensembl


ENSG00000065361


ENSMUSG00000018166

UniProt


P21860


Q61526

RefSeq (mRNA)


NM_001982 NM_001005915


NM_010153

RefSeq (protein)


NP_001005915 NP_001973


NP_034283.1 NP_034283

Location (UCSC)

Chr 12: 56.08 – 56.1 Mb

Chr 10: 128.57 – 128.59 Mb

PubMed search

1M6B, 2L9U, 3KEX, 3LMG, 3P11, 4LEO, 4OTW, 4P59, 4RIW, 4RIX, 4RIY, 5CUS

NM_001982
NM_001005915

NM_010153

NP_001005915
NP_001973

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