The environmental impact of petroleum is often negative because it is toxic to almost all forms of life and its extraction fuels climate change.
Crude oil is a mixture of many different kinds of organic compounds, many of which are highly toxic and cancer causing (carcinogenic). Oil is "acutely lethal" to fish - that is, it kills fish quickly, at a concentration of rts per million (ppm) (0.4%). Crude oil and petroleum distillates cause birth defects.
Benzene is present in both crude oil and gasoline and is known to cause leukaemia in humans. The compound is also known to lower the white blood cell count in humans, which would leave people exposed to it more susceptible to infections. "Studies have linked benzene exposure in the mere parts per billion (ppb) range to terminal leukemia, Hodgkin's lymphoma, and other blood and immune system diseases within 5-15 years of exposure."
When oil or petroleum distillates are burned (see combustion), usually the combustion is not complete. This means that incompletely burned compounds are created in addition to just water and carbon dioxide. The other compounds are often toxic to life. Examples are carbon monoxide and methanol. Also, fine particulates of soot blacken humans' and other animals' lungs and cause heart problems or death. Soot is cancer causing (carcinogenic).
High temperatures created by the combustion of petroleum cause nitrogen gas in the surrounding air to oxidize, creating nitrous oxides. Nitrous oxides, along with sulfur dioxide from the sulfur in the oil, combine with water in the atmosphere to create acid rain. Acid rain causes many problems such as dead trees and acidified lakes with dead fish. Coral reefs in the world's oceans are killed by acidic water caused by acid rain.