Endothelin 2

EDN2
Identifiers
Aliases	EDN2, ET2, PPET2, ET-2, endothelin 2
External IDs	MGI: 95284 HomoloGene: 1477 GeneCards: EDN2
Gene location (Human) Chr. Chromosome 1 (human) Band 1p34.2 Start 41,478,775 bp End 41,484,673 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 D2.1 Start 120,161,206 bp End 120,167,360 bp
Gene ontology Molecular function • hormone activity • endothelin B receptor binding Cellular component • extracellular region • intracellular • cell • extracellular space Biological process • positive regulation of prostaglandin-endoperoxide synthase activity • regulation of blood vessel size • hormonal regulation of the force of heart contraction • regulation of systemic arterial blood pressure by endothelin • vasoconstriction • cytokine-mediated signaling pathway • positive regulation of cytosolic calcium ion concentration • neutrophil chemotaxis • positive regulation of heart rate • positive regulation of leukocyte chemotaxis • cell surface receptor signaling pathway • vein smooth muscle contraction • macrophage chemotaxis • regulation of vasoconstriction • positive regulation of cell proliferation • artery smooth muscle contraction • energy homeostasis • macrophage activation • prostaglandin biosynthetic process • lung alveolus development • temperature homeostasis • positive regulation of the force of heart contraction by chemical signal • inositol phosphate-mediated signaling • positive regulation of smooth muscle contraction • calcium-mediated signaling • regulation of receptor activity • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1907	13615
Ensembl	ENSG00000127129	ENSMUSG00000028635
UniProt	P20800	P22389
RefSeq (mRNA)	NM_001956 NM_001302269	NM_007902
RefSeq (protein)	NP_001289198 NP_001947	NP_031928
Location (UCSC)	Chr 1: 41.48 – 41.48 Mb	Chr 4: 120.16 – 120.17 Mb
PubMed search

1907

13615

ENSG00000127129

ENSMUSG00000028635

P20800

P22389

NM_001956
NM_001302269

NM_007902

NP_001289198
NP_001947

NP_031928

Endothelin 2, also known as ET-2, is a protein that in humans is encoded by the EDN2 gene.

Endothelin 2 is a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation.

Endothelin 2 (ET-2) expression is mainly localized to the granulosa cells within the follicle, as observed in bovine, murine, and human ovarian tissue. Endothelin 2 has functions within the ovarian follicle related to ovulation. ET-2 causes strong contractions in smooth muscle cells of ovarian tissue, and ET-2 production is highest just before ovulation.

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