Endothelin 1

EDN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1EDN, 1EDP, 1T7H, 1V6R
Identifiers
Aliases	EDN1, ARCND3, ET1, HDLCQ7, PPET1, QME, endothelin 1
External IDs	MGI: 95283 HomoloGene: 1476 GeneCards: EDN1
Gene ontology Molecular function • hormone activity • receptor binding • cytokine activity • endothelin B receptor binding • protein binding • endothelin A receptor binding Cellular component • cytoplasm • Weibel-Palade body • basal part of cell • extracellular region • rough endoplasmic reticulum lumen • extracellular space • transport vesicle Biological process • skeletal system development • response to amino acid • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway • negative regulation of cellular protein metabolic process • positive regulation of MAP kinase activity • regulation of sensory perception of pain • vasoconstriction • body fluid secretion • positive regulation of sarcomere organization • positive regulation of cardiac muscle hypertrophy • cell surface receptor signaling pathway • cellular response to drug • multicellular organism aging • artery smooth muscle contraction • cellular response to interferon-gamma • positive regulation of chemokine-mediated signaling pathway • phosphatidylinositol 3-kinase signaling • response to leptin • positive regulation of mitotic nuclear division • cellular response to hypoxia • response to muscle stretch • cellular response to calcium ion • cellular response to transforming growth factor beta stimulus • regulation of blood vessel size • positive regulation of renal sodium excretion • blood vessel morphogenesis • negative regulation of blood coagulation • response to nicotine • in utero embryonic development • neutrophil chemotaxis • cell growth • heart development • positive regulation of prostaglandin secretion • vein smooth muscle contraction • cartilage development • rhythmic excitation • protein kinase C-activating G-protein coupled receptor signaling pathway • cellular response to glucocorticoid stimulus • negative regulation of cAMP biosynthetic process • branching involved in blood vessel morphogenesis • negative regulation of hormone secretion • positive regulation of smooth muscle contraction • negative regulation of nitric-oxide synthase biosynthetic process • positive regulation of prostaglandin-endoperoxide synthase activity • G-protein coupled receptor signaling pathway • positive regulation of urine volume • positive regulation of JUN kinase activity • leukocyte activation • positive regulation of receptor biosynthetic process • membrane depolarization • negative regulation of transcription from RNA polymerase II promoter • response to ozone • respiratory gaseous exchange • positive regulation of heart rate • regulation of blood pressure • response to lipopolysaccharide • response to prostaglandin F • regulation of vasoconstriction • cellular response to interleukin-1 • response to salt • positive regulation of cell size • middle ear morphogenesis • sensory perception of pain • prostaglandin biosynthetic process • dorsal/ventral pattern formation • phospholipase D-activating G-protein coupled receptor signaling pathway • positive regulation of odontogenesis • regulation of pH • positive regulation of smooth muscle cell proliferation • protein kinase C deactivation • histamine secretion • maternal process involved in parturition • intracellular signal transduction • response to hypoxia • neural crest cell development • regulation of systemic arterial blood pressure by endothelin • nitric oxide transport • positive regulation of cell migration • response to testosterone • positive regulation of cytosolic calcium ion concentration • epithelial fluid transport • positive regulation of nitric oxide biosynthetic process • cell-cell signaling • cellular response to tumor necrosis factor • response to activity • response to dexamethasone • superoxide anion generation • positive regulation of endothelial cell migration • cellular response to peptide hormone stimulus • cellular response to fatty acid • peptide hormone secretion • cellular response to mineralocorticoid stimulus • positive regulation of cell proliferation • inositol phosphate-mediated signaling • positive regulation of hormone secretion • negative regulation of smooth muscle cell apoptotic process • response to drug • glucose transport • calcium-mediated signaling • response to transforming growth factor beta • positive regulation of transcription from RNA polymerase II promoter • positive regulation of sequence-specific DNA binding transcription factor activity • positive regulation of cell growth involved in cardiac muscle cell development • positive regulation of neutrophil chemotaxis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1906	13614
Ensembl	ENSG00000078401	ENSMUSG00000021367
UniProt	P05305	P22387
RefSeq (mRNA)	NM_001168319 NM_001955	NM_010104
RefSeq (protein)	NP_001161791 NP_001946	NP_034234.1 NP_034234
Location (UCSC)	Chr 6: 12.29 – 12.3 Mb	Chr 13: 42.3 – 42.31 Mb
PubMed search

1EDN, 1EDP, 1T7H, 1V6R

1906

13614

ENSG00000078401

ENSMUSG00000021367

P05305

P22387

NM_001168319
NM_001955

NM_010104

NP_001161791
NP_001946

NP_034234.1
NP_034234

Endothelin 1 (ET-1), also known as preproendothelin-1 (PPET1), is a potent vasoconstrictor that in humans is encoded by the EDN1 gene and produced by vascular endothelial cells. The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. Endothelin 1 is one of three isoforms of human endothelin.

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