Endothelial NOS

NOS3

PDB 1m9j EBI.jpg

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1M9J, 1M9K, 1M9M, 1M9Q, 1M9R, 1NIW, 2LL7, 3EAH, 3NOS, 2MG5, 4D1O, 4D1P

Identifiers

NOS3, ECNOS, eNOS, nitric oxide synthase 3

External IDs

OMIM: 163729 MGI: 97362 HomoloGene: 504 GeneCards: NOS3

Targeted by Drug

Gene ontology
Molecular function	• iron ion binding • FMN binding • actin monomer binding • flavin adenine dinucleotide binding • scaffold protein binding • arginine binding • tetrahydrobiopterin binding • metal ion binding • calmodulin binding • protein binding • heme binding • NADP binding • oxidoreductase activity • cadmium ion binding • nitric-oxide synthase activity
Cellular component	• cytoplasm • endocytic vesicle membrane • cytosol • Golgi apparatus • membrane • Golgi membrane • plasma membrane • caveola • cytoskeleton • nucleus
Biological process	• negative regulation of muscle hyperplasia • ovulation from ovarian follicle • positive regulation of guanylate cyclase activity • nitric oxide biosynthetic process • regulation of blood vessel size • regulation of systemic arterial blood pressure by endothelin • regulation of sodium ion transport • lung development • negative regulation of blood pressure • removal of superoxide radicals • positive regulation of vasodilation • regulation of nitric-oxide synthase activity • mitochondrion organization • response to heat • in utero embryonic development • negative regulation of hydrolase activity • cell redox homeostasis • arginine catabolic process • positive regulation of angiogenesis • response to fluid shear stress • regulation of blood pressure • negative regulation of platelet activation • blood vessel remodeling • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • angiogenesis • negative regulation of potassium ion transport • nitric oxide mediated signal transduction • negative regulation of calcium ion transport • smooth muscle hyperplasia • regulation of the force of heart contraction by chemical signal • oxidation-reduction process • endothelial cell migration • lipopolysaccharide-mediated signaling pathway • negative regulation of cell proliferation
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE NOS3 205581 s at tn.png

More reference expression data

Orthologs

Species

Human

Mouse


4846


18127


ENSG00000164867


ENSMUSG00000028978


P29474


P70313

RefSeq (mRNA)


NM_000603 NM_001160109 NM_001160110 NM_001160111


NM_008713

RefSeq (protein)


NP_000594 NP_001153581 NP_001153582 NP_001153583


NP_032739.3 NP_032739

Location (UCSC)

Chr 7: 150.99 – 151.01 Mb

Chr 5: 24.36 – 24.38 Mb

PubMed search

1M9J, 1M9K, 1M9M, 1M9Q, 1M9R, 1NIW, 2LL7, 3EAH, 3NOS, 2MG5, 4D1O, 4D1P

ENSG00000164867

ENSMUSG00000028978

NM_000603
NM_001160109
NM_001160110
NM_001160111

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Wikipedia

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