Emerin

EMD

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1JEI, 2ODC, 2ODG

Identifiers

EMD, EDMD, LEMD5, STA, emerin

External IDs

Gene ontology
Molecular function	• protein binding • beta-tubulin binding • actin binding • cadherin binding
Cellular component	• integral component of membrane • nuclear membrane • nuclear envelope • membrane • nuclear inner membrane • endoplasmic reticulum • microtubule • nuclear outer membrane • nucleus
Biological process	• muscle contraction • regulation of canonical Wnt signaling pathway • cellular response to growth factor stimulus • muscle organ development • positive regulation of protein export from nucleus • mitotic nuclear envelope disassembly • skeletal muscle cell differentiation • negative regulation of catenin import into nucleus • mitotic nuclear envelope reassembly • negative regulation of fibroblast proliferation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


2010


13726


ENSG00000102119


ENSMUSG00000001964


P50402


O08579

RefSeq (mRNA)


NM_000117


NM_007927

RefSeq (protein)


NP_000108


NP_031953.1 NP_031953

Location (UCSC)

PubMed search

Emerin is a protein that in humans is encoded by the EMD gene, also known as the STA gene. Emerin, together with MAN1, is a LEM domain-containing integral protein of the inner nuclear membrane in vertebrates. Emerin is highly expressed in cardiac and skeletal muscle. In cardiac muscle, emerin localizes to adherens junctions within intercalated discs where it appears to function in mechanotransduction of cellular strain and in beta-catenin signaling. Mutations in emerin cause X-linked recessive Emery–Dreifuss muscular dystrophy, cardiac conduction abnormalities and dilated cardiomyopathy.