Coordinates: 52°14′N 78°30′W / 52.233°N 78.500°W
Eastmain (Cree: ᐄᔅᒣᐃᓐ/Îsmein) is a Cree community located on James Bay at the mouth of the Eastmain River, Quebec, Canada. It is a small coastal Cree village with a population of 767 people at the 2011 census. Its alternate Cree name is ᐙᐸᓅᑖᐤ/Wâpanûtâw, meaning Lands east of James Bay.
Like the other coastal villages on Hudson and James Bay, Eastmain also started out as a Hudson's Bay Company trading post, originally called East Main House.
Eastmain is accessible by air (Eastmain River Airport) and by car over a gravel road linking it to the James Bay Road.
The Eastmain community was greatly affected by the James Bay Project, which saw 90% of the Eastmain River diverted to the La Grande River in 1980.