Baron Inchiquin (Irish: Barún Inse Uí Chuinn) is one of the older titles in the Peerage of Ireland. It was one of two titles created on 1 July 1543 for Murrough O'Brien, Prince of Thomond, who was descended from the great high king Brian Boru). The grant of the English titles was conditional upon the abandonment of native titles, the adoption of English customs and laws, pledging of allegiance to the English crown, apostasy from the Catholic Church, and conversion to the Anglican Church. Murrough was made both Earl of Thomond in the Peerage of Ireland, with remainder to his nephew Donough O'Brien and Baron Inchiquin, with remainder to his male heirs.
On his death in 1551, Murrough was succeeded in the earldom, according to the special remainder, by his nephew, the second Earl (see Earl of Thomond for later history of this title), but the barony of Inchiquin passed to his son Dermod, the second baron. Dermod's great-great-grandson, the sixth baron, was a prominent military commander during the Irish Confederate Wars (1643–48), first for the English Parliament, then as a Royalist commander during the Cromwellian conquest of Ireland (1649–53) during the Wars of the Three Kingdoms. In 1654 he was created Earl of Inchiquin in the Peerage of Ireland. He was succeeded by his son, the second earl, who served as governor of English Tangier and as Governor of Jamaica. His grandson, the fourth earl, represented Windsor, Camelford and Aylesbury in the British House of Commons.