EXT2 (gene)

EXT2
Identifiers
Aliases	EXT2, SOTV, SSMS, exostosin glycosyltransferase 2
External IDs	MGI: 108050 HomoloGene: 345 GeneCards: EXT2
Gene ontology Molecular function • transferase activity • heparan sulfate N-acetylglucosaminyltransferase activity • acetylglucosaminyltransferase activity • protein homodimerization activity • transferase activity, transferring glycosyl groups • N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity • glucuronosyltransferase activity • glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity • metal ion binding • protein heterodimerization activity • protein binding Cellular component • integral component of membrane • endoplasmic reticulum membrane • membrane • Golgi membrane • UDP-N-acetylglucosamine transferase complex • endoplasmic reticulum • extracellular exosome • Golgi apparatus Biological process • heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process • cell differentiation • ossification • mesoderm formation • heparan sulfate proteoglycan biosynthetic process • protein glycosylation • glycosaminoglycan biosynthetic process • cellular polysaccharide biosynthetic process • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2132	14043
Ensembl	ENSG00000151348	ENSMUSG00000027198
UniProt	Q93063	P70428
RefSeq (mRNA)	NM_000401 NM_001178083 NM_207122	NM_010163
RefSeq (protein)	NP_000392 NP_001171554 NP_997005	NP_034293
Location (UCSC)	Chr 11: 44.1 – 44.25 Mb	Chr 2: 93.66 – 93.82 Mb
PubMed search

2132

14043

ENSG00000151348

ENSMUSG00000027198

Q93063

P70428

NM_000401
NM_001178083
NM_207122

NM_010163

NP_000392
NP_001171554
NP_997005

NP_034293

Exostosin-2 is a protein that in humans is encoded by the EXT2 gene.

This gene encodes one of two glycosyltransferases involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type II form of Multiple Exostoses.

EXT2 (gene) has been shown to interact with TRAP1.

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Wikipedia