EWS gene

EWSR1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2CPE
Identifiers
Aliases	EWSR1, EWS, bK984G1.4, EWS-FLI1, Ewing sarcoma breakpoint region 1, EWS RNA binding protein 1
External IDs	HomoloGene: 136069 GeneCards: EWSR1
Gene location (Human) Chr. Chromosome 22 (human) Band 22q12.2 Start 29,268,009 bp End 29,300,525 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • metal ion binding • protein binding • calmodulin binding • identical protein binding • nucleic acid binding • RNA binding Cellular component • cytoplasm • plasma membrane • nucleolus • membrane • Cell nucleus Biological process • regulation of transcription, DNA-templated • transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2130	n/a
Ensembl	ENSG00000182944	n/a
UniProt	Q01844	n/a
RefSeq (mRNA)	NM_001163285 NM_001163286 NM_001163287 NM_005243 NM_013986	n/a
RefSeq (protein)	NP_001156757 NP_001156758 NP_001156759 NP_005234 NP_053733	n/a
Location (UCSC)	Chr 22: 29.27 – 29.3 Mb	n/a
PubMed search		n/a

2CPE

2130

n/a

ENSG00000182944

n/a

Q01844

n/a

NM_001163285
NM_001163286
NM_001163287
NM_005243
NM_013986

n/a

NP_001156757
NP_001156758
NP_001156759
NP_005234
NP_053733

n/a

RNA-binding protein EWS is a protein that in humans is encoded by the EWSR1 gene on human chromosome 22.

This gene encodes a putative RNA binding protein. Alternative splicing of this gene results in two products.

Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma and other members of the Ewing family of tumors. Other mutations have also been associated to amyotrophic lateral sclerosis.

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