ETFDH

ETFDH
Identifiers
Aliases	ETFDH, electron-transferring-flavoprotein dehydrogenase, ETFQO, MADD, electron transfer flavoprotein dehydrogenase
External IDs	MGI: 106100 HomoloGene: 3275 GeneCards: ETFDH
Gene location (Human) Chr. Chromosome 4 (human) Band 4q32.1 Start 158,672,125 bp End 158,709,623 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3 E3|3 34.91 cM Start 79,603,788 bp End 79,629,500 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • 4 iron, 4 sulfur cluster binding • ubiquinone binding • quinone binding • flavin adenine dinucleotide binding • iron-sulfur cluster binding • metal ion binding • electron carrier activity • oxidoreductase activity • electron-transferring-flavoprotein dehydrogenase activity • oxidoreductase activity, oxidizing metal ions with flavin as acceptor Cellular component • membrane • integral component of mitochondrial inner membrane • mitochondrial matrix • mitochondrion • mitochondrial inner membrane • mitochondrial membrane • mitochondrial electron transfer flavoprotein complex Biological process • fatty acid beta-oxidation using acyl-CoA dehydrogenase • response to oxidative stress • oxidation-reduction process • electron transport chain • respiratory electron transport chain Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2110	66841
Ensembl	ENSG00000171503	ENSMUSG00000027809
UniProt	Q16134	Q921G7
RefSeq (mRNA)	NM_004453 NM_001281737 NM_001281738	NM_025794
RefSeq (protein)	NP_001268666 NP_001268667 NP_004444	NP_080070
Location (UCSC)	Chr 4: 158.67 – 158.71 Mb	Chr 4: 79.6 – 79.63 Mb
PubMed search

2110

66841

ENSG00000171503

ENSMUSG00000027809

Q16134

Q921G7

NM_004453
NM_001281737
NM_001281738

NM_025794

NP_001268666
NP_001268667
NP_004444

NP_080070

Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial is an enzyme that in humans is encoded by the ETFDH gene.

Electron-transferring-flavoprotein dehydrogenase in the inner mitochondrial membrane accepts electrons from electron-transfer flavoprotein which is located in the mitochondrial matrix and reduces ubiquinone in the mitochondrial membrane. The protein is synthesized as a 67-kDa precursor which is targeted to mitochondria and processed in a single step to a 64-kDa mature form located in the mitochondrial membrane. Deficiency in electron-transferring-flavoprotein dehydrogenase have been demonstrated in some patients with type II glutaricacidemia.

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Wikipedia