ETFA

ETFA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1EFV, 1T9G, 2A1T, 2A1U
Identifiers
Aliases	ETFA, EMA, GA2, MADD, electron transfer flavoprotein alpha subunit
External IDs	MGI: 106092 HomoloGene: 100 GeneCards: ETFA
Gene location (Human) Chr. Chromosome 15 (human) Band 15q24.2-q24.3 Start 76,215,355 bp End 76,311,472 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 B Start 55,454,508 bp End 55,512,243 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • electron carrier activity • oxidoreductase activity • flavin adenine dinucleotide binding • protein binding Cellular component • mitochondrial matrix • extracellular exosome • mitochondrion Biological process • respiratory electron transport chain • oxidation-reduction process • fatty acid beta-oxidation using acyl-CoA dehydrogenase Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2108	110842
Ensembl	ENSG00000140374	ENSMUSG00000032314
UniProt	P13804	Q99LC5
RefSeq (mRNA)	NM_000126 NM_001127716	NM_145615
RefSeq (protein)	NP_000117 NP_001121188	NP_663590
Location (UCSC)	Chr 15: 76.22 – 76.31 Mb	Chr 15: 55.45 – 55.51 Mb
PubMed search

1EFV, 1T9G, 2A1T, 2A1U

2108

110842

ENSG00000140374

ENSMUSG00000032314

P13804

Q99LC5

NM_000126
NM_001127716

NM_145615

NP_000117
NP_001121188

NP_663590

Electron-transfer-flavoprotein, alpha polypeptide (glutaric aciduria II), also known as ETFA, is a protein which in humans is encoded by the ETFA gene.

ETFA participates in catalyzing the initial step of the fatty acid beta oxidation. It shuttles electrons between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. Defects in electron-transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl CoA dehydrogenase deficiencies result in large excretion of glutaric, lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids.

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