ERK1

MAPK3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ZOQ, 4QTB
Identifiers
Aliases	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK, mitogen-activated protein kinase 3
External IDs	OMIM: 601795 MGI: 1346859 HomoloGene: 55682 GeneCards: MAPK3
Gene ontology Molecular function • phosphatase binding • ATP binding • protein kinase activity • MAP kinase activity • transferase activity • phosphotyrosine binding • scaffold protein binding • protein binding • nucleotide binding • kinase activity • protein serine/threonine kinase activity Cellular component • cytoplasm • cytosol • nuclear envelope • focal adhesion • mitochondrion • caveola • cytoskeleton • nucleus • extracellular exosome • late endosome • Golgi apparatus • protein complex • early endosome • pseudopodium • nucleoplasm Biological process • caveolin-mediated endocytosis • positive regulation of protein phosphorylation • positive regulation of telomere capping • response to exogenous dsRNA • cardiac neural crest cell development involved in heart development • positive regulation of xenophagy • positive regulation of translation • cellular response to DNA damage stimulus • platelet activation • Fc-epsilon receptor signaling pathway • protein phosphorylation • cellular response to mechanical stimulus • face development • positive regulation of histone phosphorylation • regulation of sequence-specific DNA binding transcription factor activity • DNA damage induced protein phosphorylation • positive regulation of ERK1 and ERK2 cascade • animal organ morphogenesis • cell cycle • apoptotic process • MAPK import into nucleus • Fc-gamma receptor signaling pathway involved in phagocytosis • thymus development • ERK1 and ERK2 cascade • negative regulation of apolipoprotein binding • transcription, DNA-templated • positive regulation of transcription, DNA-templated • cartilage development • viral process • response to toxic substance • regulation of stress-activated MAPK cascade • JAK-STAT cascade involved in growth hormone signaling pathway • phosphorylation • outer ear morphogenesis • BMP signaling pathway • response to lipopolysaccharide • thyroid gland development • response to epidermal growth factor • activation of MAPK activity • positive regulation of telomerase activity • peptidyl-tyrosine autophosphorylation • sensory perception of pain • positive regulation of cyclase activity • trachea formation • lipopolysaccharide-mediated signaling pathway • intracellular signal transduction • lung morphogenesis • neural crest cell development • protein complex assembly • transcription initiation from RNA polymerase I promoter • regulation of early endosome to late endosome transport • positive regulation of telomere maintenance via telomerase • MAPK cascade • positive regulation of histone acetylation • axon guidance • interleukin-1-mediated signaling pathway • fibroblast growth factor receptor signaling pathway • peptidyl-serine phosphorylation • regulation of cellular response to heat • Bergmann glial cell differentiation • regulation of Golgi inheritance • arachidonic acid metabolic process • regulation of cytoskeleton organization • positive regulation of transcription from RNA polymerase II promoter • regulation of phosphatidylinositol 3-kinase signaling • regulation of ossification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5595	26417
Ensembl	ENSG00000102882	ENSMUSG00000063065
UniProt	P27361	Q63844
RefSeq (mRNA)	NM_001040056 NM_001109891 NM_002746	NM_011952
RefSeq (protein)	NP_001035145 NP_001103361 NP_002737	NP_036082.1 NP_036082
Location (UCSC)	Chr 16: 30.11 – 30.12 Mb	Chr 7: 126.76 – 126.77 Mb
PubMed search

2ZOQ, 4QTB

5595

26417

ENSG00000102882

ENSMUSG00000063065

P27361

Q63844

NM_001040056
NM_001109891
NM_002746

NM_011952

NP_001035145
NP_001103361
NP_002737

NP_036082.1
NP_036082

Mitogen-activated protein kinase 3 is an enzyme that in humans is encoded by the MAPK3 gene.

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.

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