ERCC1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1Z00, 2A1I, 2A1J, 2JNW, 2JPD, 2MUT

Identifiers

Aliases

ERCC1, COFS4, RAD10, UV20, excision repair cross-complementation group 1, ERCC excision repair 1, endonuclease non-catalytic subunit

External IDs

MGI: 95412 HomoloGene: 1501 GeneCards: ERCC1

Gene ontology
Molecular function	• protein domain specific binding • single-stranded DNA binding • damaged DNA binding • single-stranded DNA endodeoxyribonuclease activity • protein C-terminus binding • protein binding • TFIID-class transcription factor binding • nuclease activity • endonuclease activity • hydrolase activity • 3' overhang single-stranded DNA endodeoxyribonuclease activity • DNA binding
Cellular component	• ERCC4-ERCC1 complex • transcription factor TFIID complex • nucleoplasm • nucleotide-excision repair factor 1 complex • nucleotide-excision repair complex • nuclear chromosome, telomeric region • nucleus • cytoplasm • cytosol
Biological process	• germ cell development • DNA recombination • male gonad development • interstrand cross-link repair • positive regulation of t-circle formation • cell development • response to nutrient • multicellular organism growth • embryonic organ development • post-embryonic hemopoiesis • syncytium formation • response to oxidative stress • chromosome organization • replicative cell aging • pyrimidine dimer repair by nucleotide-excision repair • oogenesis • cellular response to DNA damage stimulus • global genome nucleotide-excision repair • isotype switching • spermatogenesis • multicellular organism aging • UV protection • t-circle formation • negative regulation of telomere maintenance • transcription-coupled nucleotide-excision repair • mitotic recombination • cell proliferation • nucleotide-excision repair, DNA incision • response to X-ray • response to sucrose • nucleotide-excision repair • nucleotide-excision repair, preincision complex stabilization • double-strand break repair • DNA repair • nucleotide-excision repair, DNA incision, 5'-to lesion • nucleotide-excision repair, DNA incision, 3'-to lesion • meiotic mismatch repair • double-strand break repair via nonhomologous end joining • UV-damage excision repair • negative regulation of protection from non-homologous end joining at telomere • telomeric DNA-containing double minutes formation • nucleic acid phosphodiester bond hydrolysis
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


2067


13870

Ensembl


ENSG00000012061


ENSMUSG00000003549

UniProt


P07992


P07903

RefSeq (mRNA)


NM_001166049 NM_001983 NM_202001


NM_001127324 NM_007948

RefSeq (protein)


NP_001159521 NP_001974 NP_973730


NP_001120796.1 NP_031974.2 NP_001120796 NP_031974

Location (UCSC)

Chr 19: 45.41 – 45.48 Mb

Chr 7: 19.34 – 19.36 Mb

PubMed search

1Z00, 2A1I, 2A1J, 2JNW, 2JPD, 2MUT

NM_001166049
NM_001983
NM_202001

NM_001127324
NM_007948

NP_001159521
NP_001974
NP_973730

NP_001120796.1
NP_031974.2
NP_001120796
NP_031974

...
Wikipedia