EPHB6

EPHB6
Identifiers
Aliases	EPHB6, HEP, EPH receptor B6
External IDs	MGI: 1096338 HomoloGene: 20940 GeneCards: EPHB6
Gene location (Human) Chr. Chromosome 7 (human) Band 7q34 Start 142,855,061 bp End 142,871,094 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 B2.1 Start 41,605,482 bp End 41,620,509 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • protein kinase activity • protein binding • ATP binding • ephrin receptor activity • receptor activity Cellular component • integral component of membrane • extracellular region • cytosol • plasma membrane • integral component of plasma membrane • membrane Biological process • protein phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • ephrin receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2051	13848
Ensembl	ENSG00000106123 ENSG00000275482	ENSMUSG00000029869
UniProt	O15197	O08644
RefSeq (mRNA)	NM_001280794 NM_001280795 NM_004445	NM_001146351 NM_007680
RefSeq (protein)	NP_001267723 NP_001267724 NP_004436	NP_001139823 NP_031706
Location (UCSC)	Chr 7: 142.86 – 142.87 Mb	Chr 7: 41.61 – 41.62 Mb
PubMed search

2051

13848

ENSG00000106123
ENSG00000275482

ENSMUSG00000029869

O15197

O08644

NM_001280794
NM_001280795
NM_004445

NM_001146351
NM_007680

NP_001267723
NP_001267724
NP_004436

NP_001139823
NP_031706

Ephrin type-B receptor 6 is a protein that in humans is encoded by the EPHB6 gene.

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ephrin receptor encoded by this gene lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands.

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