EPAS1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1P97, 2A24, 3F1N, 3F1O, 3F1P, 3H7W, 3H82, 4GHI, 4GS9, 4PKY, 4XT2

Identifiers

Aliases

EPAS1, ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73, endothelial PAS domain protein 1, Hypoxia-inducible factor-2alpha

External IDs

MGI: 109169 HomoloGene: 1095 GeneCards: EPAS1

Gene ontology
Molecular function	• DNA binding • sequence-specific DNA binding • protein dimerization activity • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor binding • protein binding • histone acetyltransferase binding • protein heterodimerization activity • RNA polymerase II transcription factor activity, sequence-specific DNA binding
Cellular component	• cytoplasm • cytosol • nuclear speck • transcription factor complex • nucleoplasm • nucleus
Biological process	• surfactant homeostasis • cell differentiation • hemopoiesis • response to hypoxia • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter in response to oxidative stress • somatic stem cell population maintenance • lung development • norepinephrine metabolic process • iron ion homeostasis • mitochondrion organization • embryonic placenta development • cell maturation • response to oxidative stress • transcription, DNA-templated • regulation of heart rate • multicellular organism development • blood vessel remodeling • myoblast fate commitment • angiogenesis • regulation of transcription from RNA polymerase II promoter in response to hypoxia • erythrocyte differentiation • signal transduction • visual perception • positive regulation of transcription from RNA polymerase II promoter • cellular response to hypoxia • transcription from RNA polymerase II promoter • protein ubiquitination • post-translational protein modification
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


2034


13819

Ensembl


ENSG00000116016


ENSMUSG00000024140

UniProt


Q99814


P97481

RefSeq (mRNA)


NM_001430


NM_010137

RefSeq (protein)


NP_001421


NP_034267.3 NP_034267

Location (UCSC)

Chr 2: 46.29 – 46.39 Mb

Chr 17: 86.75 – 86.83 Mb

PubMed search

1P97, 2A24, 3F1N, 3F1O, 3F1P, 3H7W, 3H82, 4GHI, 4GS9, 4PKY, 4XT2

NP_034267.3
NP_034267

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