EIF5B

EIF5B
Identifiers
Aliases	EIF5B, IF2, eukaryotic translation initiation factor 5B
External IDs	MGI: 2441772 HomoloGene: 134613 GeneCards: EIF5B
Gene ontology Molecular function • nucleotide binding • protein binding • metal ion binding • GTP binding • hydrolase activity • translation initiation factor activity • RNA binding • GTPase activity Cellular component • cytosol • nucleus • cytoplasm Biological process • regulation of translational initiation • translational initiation • translation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9669	226982
Ensembl	ENSG00000158417	ENSMUSG00000026083
UniProt	O60841	Q05D44
RefSeq (mRNA)	NM_015904	NM_198303
RefSeq (protein)	NP_056988	NP_938045
Location (UCSC)	Chr 2: 99.34 – 99.4 Mb	Chr 1: 38 – 38.06 Mb
PubMed search

9669

226982

ENSG00000158417

ENSMUSG00000026083

O60841

Q05D44

NM_015904

NM_198303

NP_056988

NP_938045

Eukaryotic translation initiation factor 5B is a protein that in humans is encoded by the EIF5B gene.

Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. The process is simpler in prokaryotes which have only three initiation factors (IF1, IF2, IF3). Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is eIF5B. This gene encodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with other initiation factors and GTP to position the initiation methionine tRNA on the start codon of the mRNA so that translation initiates accurately.

...
Wikipedia