EIF4H

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2DNG

Identifiers

Aliases

EIF4H, WBSCR1, WSCR1, eIF-4H, eukaryotic translation initiation factor 4H

External IDs

MGI: 1341822 HomoloGene: 32536 GeneCards: EIF4H

Gene ontology
Molecular function	• nucleotide binding • translation factor activity, RNA binding • protein binding • nucleic acid binding • ribosomal small subunit binding • RNA strand-exchange activity • helicase activity • RNA strand annealing activity • RNA binding • translation initiation factor activity • cadherin binding
Cellular component	• cytoplasm • perinuclear region of cytoplasm • cytosol • eukaryotic translation initiation factor 4F complex • membrane • polysome
Biological process	• translational initiation • viral process • developmental growth • sexual reproduction • regulation of translational initiation • translation • cytoplasmic translation • eukaryotic translation initiation factor 4F complex assembly • formation of translation preinitiation complex
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


7458


22384

Ensembl


ENSG00000106682


ENSMUSG00000040731

UniProt


Q15056


Q9WUK2

RefSeq (mRNA)


NM_022170 NM_031992


NM_033561 NM_001312867

RefSeq (protein)


NP_071496 NP_114381


NP_001299796.1 NP_291039.1 NP_001299796 NP_291039

Location (UCSC)

Chr 7: 74.17 – 74.2 Mb

Chr 5: 134.62 – 134.64 Mb

PubMed search

NM_033561
NM_001312867

NP_071496
NP_114381

NP_001299796.1
NP_291039.1
NP_001299796
NP_291039

Eukaryotic translation initiation factor 4H is a protein that in humans is encoded by the EIF4H gene.

This gene encodes one of the translation initiation factors, which function to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants.

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