EGR2

EGR2
Identifiers
Aliases	EGR2, AT591, CMT1D, CMT4E, KROX20, early growth response 2
External IDs	MGI: 95296 HomoloGene: 20123 GeneCards: EGR2
Gene ontology Molecular function • DNA binding • transcription factor activity, sequence-specific DNA binding • HMG box domain binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • chromatin binding • metal ion binding • RNA polymerase II activating transcription factor binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • ligase activity • protein binding • nucleic acid binding • transcription regulatory region DNA binding • ubiquitin protein ligase binding Cellular component • cytoplasm • nucleus • nucleoplasm • intracellular membrane-bounded organelle • host cell Biological process • cellular response to organic substance • rhythmic behavior • peripheral nervous system development • regulation of transcription, DNA-templated • rhombomere 3 development • brain segmentation • transcription from RNA polymerase II promoter • protein sumoylation • rhombomere 3 formation • GO:0006350 transcription, DNA-templated • response to insulin • positive regulation of transcription, DNA-templated • brain development • rhombomere 5 formation • protein export from nucleus • learning or memory • skeletal muscle cell differentiation • Schwann cell differentiation • regulation of neuronal synaptic plasticity • myelination • facial nerve structural organization • regulation of ossification • motor neuron axon guidance • fat cell differentiation • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1959	13654
Ensembl	ENSG00000122877	ENSMUSG00000037868
UniProt	P11161	P08152
RefSeq (mRNA)	NM_000399 NM_001136177 NM_001136178 NM_001136179 NM_001321037	NM_010118 NM_001347458
RefSeq (protein)	NP_000390 NP_001129649 NP_001129650 NP_001129651 NP_001307966	NP_001334387 NP_034248
Location (UCSC)	Chr 10: 62.81 – 62.92 Mb	Chr 10: 67.54 – 67.54 Mb
PubMed search

1959

13654

ENSG00000122877

ENSMUSG00000037868

P11161

P08152

NM_000399
NM_001136177
NM_001136178
NM_001136179
NM_001321037

NM_010118
NM_001347458

NP_000390
NP_001129649
NP_001129650
NP_001129651
NP_001307966

NP_001334387
NP_034248

Early growth response protein 2 is a protein that in humans is encoded by the EGR2 gene. EGR2 (also termed Krox20) is a transcription regulatory factor, containing two zinc finger DNA-binding sites, and is highly expressed in a population of migrating neural crest cells. It is later expressed in the neural crest derived cells of the cranial ganglion. The protein encoded by Krox20 contains two cys2his2-type zinc fingers. Krox20 gene expression is restricted to the early hindbrain development. It is evolutionarily conserved in vertebrates, humans, mice, chicks, and zebra fish. In addition, the amino acid sequence and most aspects of the embryonic gene pattern is conserved among vertebrates, further implicating its role in hindbrain development. When the Krox20 is deleted in mice, the protein coding ability of the Krox20 gene (including the DNA-binding domain of the zinc finger) is diminished. These mice are unable to survive after birth and exhibit major hindbrain defects. These defects include but are not limited to defects in formation of cranial sensory ganglia, partial fusion of the trigeminal nerve (V) with the facial (VII) and auditory (VII) nerves, the proximal nerve roots coming off of these ganglia were disorganized and intertwined among one another as they entered the brainstem, and there was fusion of the glossopharyngeal (IX) nerve complex.

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Wikipedia