EGR1

EGR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4R2A, 4R2C, 4R2D, 4X9J
Identifiers
Aliases	EGR1, AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225, early growth response 1
External IDs	OMIM: 128990 MGI: 95295 HomoloGene: 56394 GeneCards: EGR1
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription regulatory region sequence-specific DNA binding • metal ion binding • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding • histone acetyltransferase binding • nucleic acid binding • transcription regulatory region DNA binding • hemi-methylated DNA-binding • double-stranded methylated DNA binding • zinc ion binding • promoter-specific chromatin binding Cellular component • nucleoplasm • nucleus • cytoplasm Biological process • regulation of apoptotic process • cellular response to organic substance • regulation of transcription, DNA-templated • glomerular mesangial cell proliferation • negative regulation of transcription from RNA polymerase II promoter • response to glucose • transcription from RNA polymerase II promoter • BMP signaling pathway • transcription, DNA-templated • positive regulation of transcription, DNA-templated • response to insulin • interleukin-1-mediated signaling pathway • cellular response to mycophenolic acid • T cell differentiation • type I interferon signaling pathway • positive regulation of glomerular metanephric mesangial cell proliferation • cellular response to gamma radiation • regulation of transcription from RNA polymerase II promoter in response to hypoxia • skeletal muscle cell differentiation • cellular response to heparin • regulation of protein sumoylation • negative regulation of canonical Wnt signaling pathway • positive regulation of transcription from RNA polymerase II promoter • cellular response to interleukin-8 • response to hypoxia • response to ischemia • estrous cycle • positive regulation of chemokine biosynthetic process • positive regulation of hormone biosynthetic process • positive regulation of interleukin-1 beta biosynthetic process • regulation of progesterone biosynthetic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1958	13653
Ensembl	ENSG00000120738	ENSMUSG00000038418
UniProt	P18146	P08046
RefSeq (mRNA)	NM_001964	NM_007913
RefSeq (protein)	NP_001955	NP_031939.1 NP_031939
Location (UCSC)	Chr 5: 138.47 – 138.47 Mb	Chr 18: 34.86 – 34.86 Mb
PubMed search

4R2A, 4R2C, 4R2D, 4X9J

1958

13653

ENSG00000120738

ENSMUSG00000038418

P18146

P08046

NM_001964

NM_007913

NP_001955

NP_031939.1
NP_031939

EGR-1 (Early growth response protein 1) also known as Zif268 (zinc finger protein 225) or NGFI-A (nerve growth factor-induced protein A) is a protein that in humans is encoded by the EGR1 gene.

EGR-1 is a mammalian transcription factor. It was also named Krox-24, TIS8, and ZENK. It was originally discovered in mice.

The protein encoded by this gene belongs to the EGR family of Cys₂His₂-type zinc finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentiation and mitogenesis. Studies suggest this is a tumor suppressor gene.

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Wikipedia