EDARADD

Identifiers

EDARADD, ECTD11A, ECTD11B, ED3, EDA3, EDAR-associated death domain, EDAR associated death domain

External IDs

MGI: 1931001 HomoloGene: 15430 GeneCards: EDARADD

Gene ontology
Molecular function	• protein binding
Cellular component	• cytoplasm • cytosol
Biological process	• multicellular organism development • cell differentiation • tumor necrosis factor-mediated signaling pathway • signal transduction
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


128178


171211

Ensembl


ENSG00000186197


ENSMUSG00000095105

UniProt


Q8WWZ3


Q8VHX2 Q5D0F1

RefSeq (mRNA)


NM_145861 NM_080738


NM_133643

RefSeq (protein)


NP_542776 NP_665860


NP_598398

Location (UCSC)

Chr 1: 236.35 – 236.48 Mb

Chr 13: 12.47 – 12.52 Mb

PubMed search

Ectodysplasin-A receptor-associated adapter protein is a protein that in humans is encoded by the EDARADD gene.

This gene was identified by its association with ectodermal dysplasia,and specifically with hypohidrotic ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

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Wikipedia