EAAT2

SLC1A2
Identifiers
Aliases	SLC1A2, EAAT2, GLT-1, HBGT, solute carrier family 1 member 2
External IDs	MGI: 101931 HomoloGene: 3075 GeneCards: SLC1A2
Genetically Related Diseases
essential tremor
Targeted by Drug
, WAY-213613
Gene ontology Molecular function • glutamate:sodium symporter activity • anion transmembrane transporter activity • protein binding • symporter activity • L-glutamate transmembrane transporter activity • high-affinity glutamate transmembrane transporter activity • amino acid transmembrane transporter activity Cellular component • integral component of membrane • membrane • plasma membrane • cell surface • axon • axolemma Biological process • cellular response to extracellular stimulus • chemical synaptic transmission • positive regulation of glucose import • response to amino acid • response to light stimulus • multicellular organism growth • D-aspartate import • ion transport • nervous system development • glutamate secretion • telencephalon development • anion transmembrane transport • adult behavior • response to wounding • L-glutamate transmembrane transport • multicellular organism aging • transport • response to drug • L-glutamate import • L-glutamate transport • visual behavior Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6506	20511
Ensembl	ENSG00000110436	ENSMUSG00000005089
UniProt	P43004	P43006
RefSeq (mRNA)	NM_001195728 NM_001252652 NM_004171	NM_001077514 NM_001077515 NM_011393
RefSeq (protein)	NP_001182657 NP_001239581 NP_004162	NP_001070982.1 NP_001070983.1 NP_035523.1 NP_001070982 NP_001070983 NP_035523
Location (UCSC)	Chr 11: 35.25 – 35.42 Mb	Chr 2: 102.66 – 102.79 Mb
PubMed search

6506

20511

ENSG00000110436

ENSMUSG00000005089

P43004

P43006

NM_001195728
NM_001252652
NM_004171

NM_001077514
NM_001077515
NM_011393

NP_001182657
NP_001239581
NP_004162

NP_035523

Excitatory amino acid transporter 2 (EAAT2) also known as solute carrier family 1 member 2 (SLC1A2) and glutamate transporter 1 (GLT-1) is a protein that in humans is encoded by the SLC1A2 gene. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

SLC1A2 / EAAT2 is a member of a family of the solute carrier family of proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. EAAT2 is responsible for over 90% of glutamate reuptake within the brain.

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Wikipedia