The Sicilian title duke of Bivona stems from the middle 16th century. Bivona is in Sicily, which had been conquered by Peter III of Aragon in 1282. It was given to people related to the powerful medieval Aragonese family of Luna, Zaragoza.
The title was bestowed on 22 May 1554 to Pedro de Luna – Peralta y Medici-Salviati, (c. 1520–1575), who had married Isabel de Vega y Osorio, (born c1525), daughter of the Ambassador Juan de Vega y Enríque, and Leonor Perez – Osorio y Sarmiento, (died 30 March 1550, Palermo). He was 10th Count of Caltabellotta, and also Count (Conte in Italian) of Calatafimi, Sclafani, and Caltavuturo. Two of their children were 2nd and 3rd Dukes of Bivona.
Piero Giulio de Luna e Vega (Pedro Julio) in 1575 became 2nd Duke of Bivona and 11th Count of Caltabellota. He married the Spanish "Angela De la Cerda y Manuel" in 1562, daughter of Juan II de la Cerda, 4th Duke of Medinaceli. He died in 1592.
Aloisia de Luna e Vega, (3rd Duchess of Bivona by her own rights), (deceased Caltanissetta, 1619). The Duchess, was named after her grandmother, an Italian Salviati – Medici woman, sister of Pope Leo X "Medici",
In 1568 Duchess Aloisia married Cesare Moncada – Aragona y Pignatelli, 2nd principe di Paternò, Conte di Adernò, Conte di Sclafani, Conte di Caltabellota, Vicario generale y capitano d’arme nelle città di Siracusa e Catania, (+ Caltgirone July 1591).
Cesare Moncada, the Duke Consort, was the son of Don Francesco Moncada, Conte di Adernò, Conte di Sclafani (con la terra di Caltavuturo e Scillato), Conte di Caltanissetta, 1st principe di Paternò, (* 1518 – married 1532 – + 23 February 1568) and of Caterina Pignatelli, the daughter of Camillo Pignatelli, Conte di Borello, 3rd duca di Monteleone, (+ 28 March 1583), and Donna Girolama Colonna, the daughter of the 2nd duca di Paliano.