Duffy antigen

ACKR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4NUU, 4NUV
Identifiers
Aliases	ACKR1, atypical chemokine receptor 1 (Duffy blood group), CCBP1, CD234, Dfy, FY, GPD, GpFy, WBCQ1, DARC
External IDs	OMIM: 613665 MGI: 1097689 HomoloGene: 48067 GeneCards: ACKR1
Gene ontology Molecular function • C-C chemokine binding • G-protein coupled receptor activity • transmembrane signaling receptor activity • signal transducer activity • chemokine binding • receptor activity Cellular component • integral component of membrane • recycling endosome • endosome • plasma membrane • early endosome • membrane Biological process • chemokine-mediated signaling pathway • regulation of chemokine production • G-protein coupled receptor signaling pathway • defense response • inflammatory response • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2532	13349
Ensembl	ENSG00000213088	ENSMUSG00000037872
UniProt	Q16570	Q9QUI6
RefSeq (mRNA)	NM_002036 NM_001122951	NM_010045
RefSeq (protein)	NP_001116423 NP_002027	NP_034175.2 NP_034175
Location (UCSC)	Chr 1: 159.2 – 159.21 Mb	Chr 1: 173.33 – 173.33 Mb
PubMed search

4NUU, 4NUV

2532

13349

ENSG00000213088

ENSMUSG00000037872

Q16570

Q9QUI6

NM_002036
NM_001122951

NM_010045

NP_001116423
NP_002027

NP_034175.2
NP_034175

Duffy antigen/chemokine receptor (DARC), also known as Fy glycoprotein (FY) or CD234 (Cluster of Differentiation 234), is a protein that in humans is encoded by the DARC gene.

The Duffy antigen is located on the surface of red blood cells, and is named after the patient in which it was discovered. The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The protein is also the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system.

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Wikipedia