Sophie Lebrun, Duchess of Plaisance (Greek: Δούκισσα της Πλακεντίας) (1785–1854) was born in Philadelphia, Pennsylvania, where her father, François Barbé-Marbois, was serving as French Consul-General in the United States.
In 1802, Sophie married Anne-Charles Lebrun , the eldest son of Charles-François Lebrun later duc de Plaisance (this last one who along with Napoleon Bonaparte had served as one of three Consuls of France from 1799-1804). The marriage was unhappy and the couple separated without ever taking divorce; Sophie lived in Italy while the Duc served as the Governor of Holland from 1811-1813.
Upon the outbreak of the Greek War of Independence, the Duchess and her daughter generously supported the Greek cause and in 1830, they moved to Nafplion, the capital of Greece at that time and she was reacquainted with the Greek leader John Capodistria whom she had met in Paris in 1826. She became an ardent financial supporter of public education. Eventually, she became an opponent of Capodistrias, and after a 17-month stay, she left for Italy. When Capodistrias was assassinated by Konstantinos Mavromichalis and his nephew Georgios Mavromichalis, she spoke out against the way Capodistrias had run the Greek government.
In 1834, the Duchess returned to Greece and settled in the new capital Athens. She purchased large amounts of agricultural land chiefly near Mt. Penteli, but all around Athens. She engaged the Greek architect, Stamatios Kleanthis to design a palace for her on the slopes of Mt. Penteli. Meanwhile, in 1836, the Duchess and her daughter traveled to Beirut, where Eliza died of pneumonia. Such was the sorrow of the Duchess that she had her daughter's body embalmed and returned to Athens where it was placed in a crypt under her temporary home on Peiraios Street.