Domitia (PIR² D 171), more commonly referred to as Domitia the Elder -- in fact no ancient source ever calls her Lepida - (ca. 8 BC-June 59) was the oldest child of Antonia Major and Lucius Domitius Ahenobarbus (consul 16 BC), and the oldest granddaughter to Triumvir Mark Antony by Octavia Minor, a great-niece of the Roman Emperor Augustus, second cousin and sister-in-law to the Emperor Caligula, first cousin to the Emperor Claudius, maternal aunt to the Empress Valeria Messalina, and paternal aunt to Emperor Nero. She had two younger siblings: Domitia Lepida and Cn. Domitius Ahenobarbus (cos. AD 32). The date of her birth is not recorded and can be only estimated as no later than 7 BC, but possibly as much as 10 years earlier, if one would allow a long delay between her birth and those of her two siblings.
She married the consul Decimus Haterius Agrippa, who died in 32 as a victim of Tiberius' reign of terror. Domitia bore Agrippa a son, Quintus Haterius Antoninus (cos. AD 53) in approximately 20. In 33 Domitia married the witty, wealthy, and influential Gaius Sallustius Crispus Passienus. Crispus was the adopted grandson and biological great-great nephew of the historian Sallust.
After January 41, Crispus divorced Domitia, so he could marry Domitia's former sister-in-law Agrippina the Younger, who had recently returned from exile. Thereby, Crispus became the stepfather of Agrippina's son Lucius Domitius Ahenobarbus (Nero), who was Domitia's nephew. Crispus soon died mysteriously, leaving a fortune to Agrippina and her son.