Domenico Puligo (1492–1527) was an Italian painter of the Renaissance, active in Florence. His real name was Domenico di Bartolomeo Ubaldini.
He trained under Ridolfo Ghirlandaio and acted as an assistant to Andrea del Sarto, whom he also became close friends with. Both Ghirlandaio and Sarto exerted heavy influences over Puligo that are evident in his works and style of painting. Puglio was also influenced by Jacopo Pontormo and Il Rosso. He rose to success as a portrait artist and was in high demand in Florence. His most renowned piece is possibly the large scale Vision of Saint Bernard altarpiece, now located in the Walters Art Gallery in Baltimore. Some of his early works include the Virgin and Child with St. John as well as the Holy Family. About a dozen drawings are also attributed to Puligo but none relate to his surviving works or bear resemblance to the styles of his paintings. He is featured in Giorgio Vasari's Vite or Lives of the Artists. According to Vasari, Puligo was a particularly idle artist, which may explain the paucity of his productions. His brother, Jacone Puligo, was also a Renaissance painter.
Domenico Puligo came from a family of blacksmiths. His father, Bartolomeo, was a blacksmith and a descendant of the Ubaldini of Marradi in Tuscan Romagna, who were also blacksmiths. His mother was Apollonia, daughter of the goldsmith Antonio di Giovanni. Puligo also had a sister named Francesca. In early 15th century, the Ubaldini family moved to the village of Ponte a Rifredi on the edge of Florence from their native area. Several years later, the family moved again to the Piazza di San Gallo, resting on the periphery of Porta San Gallo. Here the family lived in a small house that was part of the property of the Spedale di San Gallo.
The earliest record of Puligo is from 1504. Provided by his father to the Estimo del Contado in Florence, Bartolomeo stated that his son was twelve years old, which allowed it to be determined that Puligo was born in 1492. The second record after this initial one dates in 1525, 21 years later, when Puligo was aged 33. Two years later, in 1527, Puligo dies at the age of 35.