Dolly (sheep)
Dolly's taxidermied remains
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| Other name(s) | 6LLS (code name) |
|---|---|
| Species | Domestic sheep, Finn-Dorset |
| Sex | Female |
| Born | 5 July 1996 Roslin Institute, Edinburgh, Scotland |
| Died | 14 February 2003 (aged 6) Roslin Institute, Edinburgh, Scotland |
| Resting place | National Museum of Scotland (remains on display). |
| Nation from | United Kingdom (Great Britain) |
| Known for | First mammal cloned from an adult somatic cell |
| Offspring | Six lambs (Bonnie; twins Sally and Rosie; triplets Lucy, Darcy and Cotton) |
| Named after | Dolly Parton |
| Cause of death | Lung disease and severe arthritis |
Dolly (5 July 1996 – 14 February 2003) was a female domestic sheep, and the first mammal cloned from an adult somatic cell, using the process of nuclear transfer.
Dolly was cloned by Ian Wilmut, Keith Campbell and colleagues at the Roslin Institute, part of the University of Edinburgh, Scotland, and the biotechnology company PPL Therapeutics, based near Edinburgh. The funding for Dolly's cloning was provided by PPL Therapeutics and the UK's Ministry of Agriculture. She was born on 5 July 1996 and died from a progressive lung disease five months before her seventh birthday. She has been called "the world's most famous sheep" by sources including BBC News and Scientific American.
The cell used as the donor for the cloning of Dolly was taken from a mammary gland, and the production of a healthy clone therefore proved that a cell taken from a specific part of the body could recreate a whole individual. On Dolly's name, Wilmut stated "Dolly is derived from a mammary gland cell and we couldn't think of a more impressive pair of glands than Dolly Parton's".
Dolly was born on 5 July 1996 and had three mothers (one provided the egg, another the DNA and a third carried the cloned embryo to term). She was created using the technique of somatic cell nuclear transfer, where the cell nucleus from an adult cell is transferred into an unfertilized oocyte (developing egg cell) that has had its cell nucleus removed. The hybrid cell is then stimulated to divide by an electric shock, and when it develops into a it is implanted in a surrogate mother. Dolly was the first clone produced from a cell taken from an adult mammal. The production of Dolly showed that genes in the nucleus of such a mature differentiated somatic cell are still capable of reverting to an embryonic totipotent state, creating a cell that can then go on to develop into any part of an animal. Dolly's existence was announced to the public on 22 February 1997. It gained much attention in the media. A commercial with Scottish scientists playing with sheep was aired on TV, and a special report in TIME Magazine featured Dolly the sheep.Science featured Dolly as the breakthrough of the year. Even though Dolly was not the first animal cloned, she received media attention because she was the first cloned from an adult cell.
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