"Do Me!" is a song by hip hop/R&B group Bell Biv DeVoe. The song was released in 1990 as the second single from the group's multi-platinum debut album, Poison. A remix is included on the group's WBBD-Bootcity!: The Remix Album, released in 1991.

According to Billboard, the song is about sex.

In June 1990, "Do Me!" entered the U.S. Billboard Hot 100 singles chart at number 92. In September, the song reached number three, tying previous single "Poison" as Bell Biv DeVoe's biggest hit on the pop charts. The song remained on the Hot 100 for 22 weeks. Elsewhere, the single peaked at number 4 on the Hot R&B/Hip-Hop Songs chart and number 6 on the Hot Dance Club Songs chart. The song ranked number 11 on the Billboard Year-End chart for 1990.

Davitt Sigerson called the song a "landmark in priapic obsession," and added, "[i]f the true spirit of the male love jones could speak, its words would be B.B.D.'s: 'Slap it up, flip it, rub it down, oh no!'" The song makes reference to Swatch watches, a popular accessory of the 1980s.

The video was shot in 35mm over two and a half days.

"Do Me!" was featured during a scene in the 2002 romantic comedy film 40 Days and 40 Nights. A parody of the song by cover band and comedy act Richard Cheese and Lounge Against the Machine appears on their 2005 album Aperitif for Destruction. The song was covered by "Weird Al" Yankovic for his polka medley "Polka Your Eyes Out" from his 1992 album Off the Deep End. TV star Jensen Ackles sang this song in the season 3 gag reel of Supernatural (U.S. TV series).

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