Dmc1

DMC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1V5W, 2ZJB, 4HYY
Identifiers
Aliases	DMC1, DMC1H, LIM15, dJ199H16.1, DNA meiotic recombinase 1
External IDs	MGI: 105393 HomoloGene: 5135 GeneCards: DMC1
Gene ontology Molecular function • DNA binding • nucleotide binding • DNA-dependent ATPase activity • recombinase activity • single-stranded DNA binding • protein binding • four-way junction DNA binding • double-stranded DNA binding • endodeoxyribonuclease activity • ATP binding Cellular component • chromosome • nucleoplasm • chromosome, telomeric region • nucleus • condensed nuclear chromosome Biological process • strand invasion • response to ionizing radiation • DNA recombinase assembly • female gamete generation • male meiosis I • DNA metabolic process • gamete generation • synapsis • oocyte maturation • spermatogenesis • spermatid development • ovarian follicle development • cell cycle • chromosome organization involved in meiotic cell cycle • mitotic recombination • DNA repair • reciprocal meiotic recombination • meiotic cell cycle Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11144	13404
Ensembl	ENSG00000100206	ENSMUSG00000022429
UniProt	Q14565	Q61880
RefSeq (mRNA)	NM_001278208 NM_007068	NM_001278226 NM_010059
RefSeq (protein)	NP_001265137 NP_008999	NP_001265155 NP_034189
Location (UCSC)	Chr 22: 38.52 – 38.57 Mb	Chr 15: 79.56 – 79.61 Mb
PubMed search

1V5W, 2ZJB, 4HYY

11144

13404

ENSG00000100206

ENSMUSG00000022429

Q14565

Q61880

NM_001278208
NM_007068

NM_001278226
NM_010059

NP_001265137
NP_008999

NP_001265155
NP_034189

Meiotic recombination protein DMC1/LIM15 homolog is a protein that in humans is encoded by the DMC1 gene.

Meiotic recombination protein Dmc1 is a homolog of the bacterial strand exchange protein RecA. Dmc1 plays the central role in homologous recombination in meiosis by assembling at the sites of programmed DNA double strand breaks and carrying out a search for allelic DNA sequences located on homologous chromatids. The name "Dmc" stands for "disrupted meiotic cDNA" and refers to the method used for its discovery which involved using clones from a meiosis-specific cDNA library to direct knock-out mutations of abundantly expressed meiotic genes. The Dmc1 protein is one of two homologs of RecA found in eukaryotic cells, the other being Rad51. In budding yeast, Rad51 serves as a strand exchange protein in mitosis where it is critical for the repair of DNA breaks. Rad51 is converted to an accessory factor for Dmc1 during meiosis by inhibition of its strand exchange activity. Homologs of DMC1 have been identified in many organisms including divergent fungi, plants and mammals including humans.

...
Wikipedia