Ditch Creek is a stream in Washington and Jefferson counties, Missouri. It is a tributary of the Big River.
The source is located at: 38°10′23″N 90°48′46″W / 38.17306°N 90.81278°W and the confluence is at: 38°13′46″N 90°44′19″W / 38.22944°N 90.73861°WCoordinates: 38°13′46″N 90°44′19″W / 38.22944°N 90.73861°W.
The creek most likely took its name from a nearby lead mine situated in a ditch.