Dipeptidyl peptidase-4

DPP4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1J2E, 1N1M, 1NU6, 1NU8, 1PFQ, 1R9M, 1R9N, 1RWQ, 1TK3, 1TKR, 1U8E, 1W1I, 1WCY, 1X70, 2AJL, 2BGN, 2BGR, 2BUB, 2FJP, 2G5P, 2G5T, 2G63, 2HHA, 2I03, 2I78, 2IIT, 2IIV, 2JID, 2OAG, 2OGZ, 2OLE, 2ONC, 2OPH, 2OQI, 2OQV, 2P8S, 2QJR, 2QKY, 2QOE, 2QT9, 2QTB, 2RGU, 2RIP, 3BJM, 3C43, 3C45, 3CCB, 3CCC, 3D4L, 3EIO, 3F8S, 3G0B, 3G0C, 3G0D, 3G0G, 3H0C, 3HAB, 3HAC, 3KWF, 3KWJ, 3NOX, 3O95, 3O9V, 3OC0, 3OPM, 3Q0T, 3Q8W, 3QBJ, 3SWW, 3SX4, 3VJK, 3VJL, 3VJM, 3W2T, 4A5S, 4DSA, 4DSZ, 4DTC, 4G1F, 4JH0, 4KR0, 4L72, 4LKO, 4J3J, 4N8D, 4N8E, 4PNZ, 4PV7, 4QZV, 3WQH, 5KBY, 5ISM, 5I7U
Identifiers
Aliases	DPP4, ADABP, ADCP2, CD26, DPPIV, TP103, dipeptidyl peptidase 4
External IDs	OMIM: 102720 MGI: 94919 HomoloGene: 3279 GeneCards: DPP4
Genetically Related Diseases
rheumatoid arthritis
Targeted by Drug
alogliptin, linagliptin, omarigliptin, saxagliptin anhydrous, sitagliptin, vildagliptin
Gene ontology Molecular function • dipeptidyl-peptidase activity • receptor binding • identical protein binding • peptidase activity • hydrolase activity • virus receptor activity • protein homodimerization activity • serine-type peptidase activity • protease binding • aminopeptidase activity • protein binding • serine-type endopeptidase activity Cellular component • lamellipodium membrane • extracellular exosome • lysosomal membrane • endocytic vesicle • integral component of membrane • cell projection • cell junction • lamellipodium • apical plasma membrane • membrane • focal adhesion • cell surface • intercellular canaliculus • membrane raft • invadopodium membrane • extracellular region • plasma membrane Biological process • response to hypoxia • T cell costimulation • proteolysis • psychomotor behavior • behavioral fear response • negative regulation of extracellular matrix disassembly • regulation of cell-cell adhesion mediated by integrin • locomotory exploration behavior • endothelial cell migration • positive regulation of cell proliferation • T cell activation • cell adhesion • viral entry into host cell • regulation of insulin secretion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1803	13482
Ensembl	ENSG00000197635	ENSMUSG00000035000
UniProt	P27487	P28843
RefSeq (mRNA)	NM_001935	NM_001159543 NM_010074
RefSeq (protein)	NP_001926	NP_001153015.1 NP_034204.1 NP_001153015 NP_034204
Location (UCSC)	Chr 2: 161.99 – 162.07 Mb	Chr 2: 62.33 – 62.41 Mb
PubMed search

1J2E, 1N1M, 1NU6, 1NU8, 1PFQ, 1R9M, 1R9N, 1RWQ, 1TK3, 1TKR, 1U8E, 1W1I, 1WCY, 1X70, 2AJL, 2BGN, 2BGR, 2BUB, 2FJP, 2G5P, 2G5T, 2G63, 2HHA, 2I03, 2I78, 2IIT, 2IIV, 2JID, 2OAG, 2OGZ, 2OLE, 2ONC, 2OPH, 2OQI, 2OQV, 2P8S, 2QJR, 2QKY, 2QOE, 2QT9, 2QTB, 2RGU, 2RIP, 3BJM, 3C43, 3C45, 3CCB, 3CCC, 3D4L, 3EIO, 3F8S, 3G0B, 3G0C, 3G0D, 3G0G, 3H0C, 3HAB, 3HAC, 3KWF, 3KWJ, 3NOX, 3O95, 3O9V, 3OC0, 3OPM, 3Q0T, 3Q8W, 3QBJ, 3SWW, 3SX4, 3VJK, 3VJL, 3VJM, 3W2T, 4A5S, 4DSA, 4DSZ, 4DTC, 4G1F, 4JH0, 4KR0, 4L72, 4LKO, 4J3J, 4N8D, 4N8E, 4PNZ, 4PV7, 4QZV, 3WQH, 5KBY, 5ISM, 5I7U

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