Dimercaptopropane sulfonate

2,3-Dimercapto-1-propanesulfonic acid
Names


Preferred IUPAC name 2,3-Bis(sulfanyl)propane-1-sulfonic acid
Other names 2,3-Dimercaptopropane-1-sulfonic acid (no longer recommended)
Identifiers
CAS Number	207233-91-8^N
3D model (JSmol)	Interactive image Interactive image
ChEBI	CHEBI:888^Y
ChemSpider	6081^Y
KEGG	C10922^Y
MeSH	Unithiol
PubChem CID	6321
InChI InChI=1S/C3H8O3S3/c4-9(5,6)2-3(8)1-7/h3,7-8H,1-2H2,(H,4,5,6)^Y Key: JLVSRWOIZZXQAD-UHFFFAOYSA-N^Y InChI=1/C3H8O3S3/c4-9(5,6)2-3(8)1-7/h3,7-8H,1-2H2,(H,4,5,6) Key: JLVSRWOIZZXQAD-UHFFFAOYAD
SMILES OS(=O)(=O)CC(S)CS O=S(=O)(O)CC(S)CS
Properties
Chemical formula	C₃H₈O₃S₃
Molar mass	188.289 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N (what is ^YN ?)
Infobox references

2,3-Dimercapto-1-propanesulfonic acid (abbreviated DMPS) and its sodium salt (known as Unithiol) are chelating agents that form complexes with various heavy metals. They are related to dimercaprol, which is another chelating agent.

The synthesis of DMPS was first reported in 1956 by V. E. Petrunkin. The effects of DMPS on heavy metal poisoning, including with polonium-210, were investigated in the following years. DMPS was found to have some protective effect, prolonging the survival time.

A study was undertaken of DMPS use by workers involved in the production of a calomel skin bleaching lotion and in direct contact with mercurous chloride and that already showed elevated urine mercury levels. The sodium salt of DMPS was found to be effective in lowering the body burden of mercury and in decreasing the urinary mercury concentration to normal levels.

DMPS administrated to a mercury poisoned animal model failed to remove the mercury from tissues and reduce the inorganic mercury burden in the brain. A 2008 study reported a case of Stevens–Johnson syndrome (SJS), a potentially serious disease, in a child undergoing chelation therapy with DMPS; the SJS resolved gradually after the chelation therapy was stopped.

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