Dihydrolipoamide acetyltransferase

DLAT
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FYC, 1Y8N, 1Y8O, 1Y8P, 2DNE, 2PNR, 2Q8I, 3B8K, 3CRK, 3CRL
Identifiers
Aliases	DLAT, DLTA, PDC-E2, PDCE2, dihydrolipoamide S-acetyltransferase, Dihydrolipoyl transacetylase
External IDs	OMIM: 608770 MGI: 2385311 HomoloGene: 6814 GeneCards: DLAT
Gene location (Human) Chr. Chromosome 11 (human) Band 11q23.1 Start 112,024,814 bp End 112,064,390 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A5.3 Start 50,634,633 bp End 50,659,780 bp
Gene ontology Molecular function • transferase activity • dihydrolipoyllysine-residue acetyltransferase activity • protein binding • pyruvate dehydrogenase (NAD+) activity • transferase activity, transferring acyl groups • identical protein binding Cellular component • mitochondrial pyruvate dehydrogenase complex • myelin sheath • pyruvate dehydrogenase complex • mitochondrial matrix • mitochondrion Biological process • tricarboxylic acid cycle • regulation of acetyl-CoA biosynthetic process from pyruvate • sleep • pyruvate metabolic process • glucose metabolic process • metabolism • acetyl-CoA biosynthetic process from pyruvate • cellular nitrogen compound metabolic process • carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1737	235339
Ensembl	ENSG00000150768	ENSMUSG00000000168
UniProt	P10515	Q8BMF4
RefSeq (mRNA)	NM_001931	NM_145614
RefSeq (protein)	NP_001922	NP_663589
Location (UCSC)	Chr 11: 112.02 – 112.06 Mb	Chr 11: 50.63 – 50.66 Mb
PubMed search

dihydrolipoyllysine-residue acetyltransferase
Identifiers
EC number	2.3.1.12
CAS number	9032-29-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Search
PMC	articles
PubMed	articles
NCBI	proteins

1FYC, 1Y8N, 1Y8O, 1Y8P, 2DNE, 2PNR, 2Q8I, 3B8K, 3CRK, 3CRL

1737

235339

ENSG00000150768

ENSMUSG00000000168

P10515

Q8BMF4

NM_001931

NM_145614

NP_001922

NP_663589

Dihydrolipoyl transacetylase (or dihydrolipoamide acetyltransferase) is an enzyme component of the multienzyme pyruvate dehydrogenase complex. The pyruvate dehydrogenase complex is responsible for the pyruvate decarboxylation step that links glycolysis to the citric acid cycle. This involves the transformation of pyruvate from glycolysis into acetyl-CoA which is then used in the citric acid cycle to carry out cellular respiration.

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