Dicer

DICER1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2EB1, 4NGB, 4NGC, 4NGD, 4NGF, 4NGG, 4NH3, 4NH5, 4NH6, 4NHA, 4WYQ

Identifiers

Aliases

DICER1, DCR1, Dicer, Dicer1e, HERNA, MNG1, RMSE2, K12H4.8-LIKE, dicer 1, ribonuclease III

External IDs

MGI: 2177178 HomoloGene: 13251 GeneCards: DICER1

Gene ontology
Molecular function	• nucleotide binding • helicase activity • protein domain specific binding • pre-miRNA binding • metal ion binding • endoribonuclease activity • endoribonuclease activity, producing 5'-phosphomonoesters • protein binding • siRNA binding • RNA binding • nuclease activity • double-stranded RNA binding • endonuclease activity • hydrolase activity • ATP binding • ribonuclease III activity • nucleic acid binding
Cellular component	• cytoplasm • cytosol • RISC complex • growth cone • ARC complex • RISC-loading complex • axon • dendrite • nucleus • endoplasmic reticulum-Golgi intermediate compartment
Biological process	• miRNA loading onto RISC involved in gene silencing by miRNA • neuron projection morphogenesis • RNA processing • conversion of ds siRNA to ss siRNA • negative regulation of transcription from RNA polymerase II promoter • peripheral nervous system myelin formation • pre-miRNA processing • positive regulation of myelination • conversion of ds siRNA to ss siRNA involved in RNA interference • production of siRNA involved in RNA interference • siRNA loading onto RISC involved in RNA interference • targeting of mRNA for destruction involved in RNA interference • gene silencing by RNA • nerve development • RNA phosphodiester bond hydrolysis, endonucleolytic • positive regulation of Schwann cell differentiation • negative regulation of Schwann cell proliferation • production of miRNAs involved in gene silencing by miRNA
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


23405


192119

Ensembl


ENSG00000100697


ENSMUSG00000041415

UniProt


Q9UPY3


Q8R418

RefSeq (mRNA)


NM_001195573 NM_001271282 NM_001291628 NM_030621 NM_177438


NM_148948

RefSeq (protein)


NP_001182502 NP_001258211 NP_001278557 NP_085124 NP_803187


n/a

Location (UCSC)

Chr 14: 95.09 – 95.16 Mb

Chr 12: 104.69 – 104.75 Mb

PubMed search

2EB1, 4NGB, 4NGC, 4NGD, 4NGF, 4NGG, 4NH3, 4NH5, 4NH6, 4NHA, 4WYQ

NM_001195573
NM_001271282
NM_001291628
NM_030621
NM_177438

NM_148948

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