Derbe was a city in the Roman province of Galatia in Asia Minor, and in the ethnic region of Lycaonia. It is mentioned in the Acts of the Apostles at 14:6, 14:20 and 16:1.
In 1956, on the basis of an inscription, Michael Ballance fixed the site of Derbe at a mound known as Kerti Hüyük, some 22 kilometres (14 mi) north-northeast of Karaman (ancient Laranda) in Turkey. Although subject to controversy, this is considered the most likely site.
Antipater of Derbe, a friend of Cicero, was ruler of Derbe, but was killed by Amyntas of Galatia, who added Derbe to his possessions.
In Roman times it struck its own coins, of which a few are extant.
The apostles Paul and Barnabas came to Derbe after escaping a disturbance and attempted stoning in Iconium, about 60 miles away, and successfully evangelized there. Paul and Barnabas returned there after being stoned again in Lystra. On these experiences, Paul commented, "We must through many tribulations enter the kingdom of God." He and Silas later visited Derbe again.
The Bishopric of Derbe became a suffragan see of Iconium. It is not mentioned by later Notitiae Episcopatuum. Just four bishops are known, from 381 to 672.
Derbe is included in the Catholic Church's list of titular sees.