Deoxyribonuclease I

DNASE1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4AWN
Identifiers
Aliases	DNASE1, DNL1, DRNI, deoxyribonuclease I, deoxyribonuclease 1
External IDs	OMIM: 125505 MGI: 103157 HomoloGene: 3826 GeneCards: DNASE1
Gene ontology Molecular function • nuclease activity • endonuclease activity • deoxyribonuclease I activity • actin binding • protein binding • hydrolase activity • deoxyribonuclease activity Cellular component • extracellular region • extracellular exosome • nuclear envelope • nucleus Biological process • DNA catabolic process • nucleic acid phosphodiester bond hydrolysis • apoptotic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1773	13419
Ensembl	ENSG00000213918	ENSMUSG00000005980
UniProt	P24855	P49183
RefSeq (mRNA)	NM_005223	NM_010061
RefSeq (protein)	NP_005214	NP_034191.3 NP_034191
Location (UCSC)	Chr 16: 3.61 – 3.68 Mb	Chr 16: 4.04 – 4.04 Mb
PubMed search

4AWN

1773

13419

ENSG00000213918

ENSMUSG00000005980

P24855

P49183

NM_005223

NM_010061

NP_005214

NP_034191.3
NP_034191

Deoxyribonuclease I (usually called DNase I), is an endonuclease coded by the human gene DNASE1. DNase I is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. It acts on single-stranded DNA, double-stranded DNA, and chromatin. In addition to its role as a waste-management endonuclease, it has been suggested to be one of the deoxyribonucleases responsible for DNA fragmentation during apoptosis.

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