Denistone West is a suburb in the Northern Suburbs of Sydney, in the state of New South Wales, Australia. Denistone West is located 16 kilometres north-west of the Sydney central business district in the local government area of the City of Ryde. Denistone and Denistone East are separate suburbs; Denistone West was gazetted as a suburb in its own right on 5 February 1999.

Denistone West has several parks, including West Denistone Park, Lynn Park, Rutherford Park and Hibble Park. West Denistone Park was featured briefly in an episode of Season 43 of Play School on the ABC.

Denistone railway station is situated in the suburb of Denistone, the station does not have disabled access. Denistone West is serviced by several Sydney Buses routes, the 543 and 544, which connect to West Ryde, Eastwood, Auburn and & Macquarie Park.

At the 2011 census, 18.5% of employed people travelled to work on public transport and 66.2% by motor vehicle.

The commercial and retail hub of Denistone West is the West Denistone Shopping Centre. Major tenants include a vet & a hairdresser. An Australia Post post box is installed nearby the centre. The shopping area also includes a small car park.

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