The Gherardeschi or della Gherardesca were a family of the Republic of Pisa, dating back as early as the 11th century. They were one of the most prominent in Pisa by the middle of the 13th century. They were of Ghibelline sympathies and held the county of Donoratico.
Constantine I of Gallura may have been a member of the family, ruling Gallura on behalf of the Archdiocese of Pisa.
The Gherardeschi had a rivalry with the House of Visconti, another Ghibelline family of Pisa. In 1237, the Archbishop and the Emperor Frederick II intervened in Pisa to reconcile the two rivals, but failed. In 1254, the citizenry rebelled and imposed twelve Anziani del Popolo ("Elders of the People") as their political representatives.
Early on in the century, the Gherardeschi took an interest in the affairs of Pisa in Sardinia. In 1230, Ubaldo of Gallura, a Visconti, invaded the Giudicato of Cagliari, but the Gherardeschi repulsed him in the name of Benedetta and the young William II. In 1258, they received a third of Cagliari after its dismemberment. Their third was the south-western third; in the 1272 circa the count Ugolino della Gherardesca founded in the Cixerri the important mining town of Villa di Chiesa, today Iglesias. A Gherardesca woman also married John Visconti, the Judge of Gallura, who had received the northeastern third of Cagliari. This marriage brought final reconciliation between the Visconti and Gherardeschi.