Deleted in Colorectal Cancer

DCC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ED7, 2ED8, 2ED9, 2EDB, 2EDD, 2EDE, 3AU4, 4URT
Identifiers
Aliases	DCC, DCC netrin 1 receptor, CRC18, CRCR1, IGDCC1, MRMV1, NTN1R1
External IDs	OMIM: 120470 MGI: 94869 HomoloGene: 21081 GeneCards: DCC
Gene ontology Molecular function • protein binding • netrin receptor activity • transmembrane signaling receptor activity Cellular component • integral component of membrane • cytosol • membrane • plasma membrane • axon Biological process • dorsal/ventral axon guidance • negative regulation of neuron projection development • axonogenesis • netrin-activated signaling pathway • neuron migration • nervous system development • negative regulation of dendrite development • axon guidance • multicellular organism development • negative regulation of collateral sprouting • regulation of neuron death • extrinsic apoptotic signaling pathway in absence of ligand • spinal cord ventral commissure morphogenesis • anterior/posterior axon guidance • apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1630	13176
Ensembl	ENSG00000187323	ENSMUSG00000060534
UniProt	P43146	P70211
RefSeq (mRNA)	NM_005215	NM_007831
RefSeq (protein)	NP_005206	NP_031857.2 NP_031857
Location (UCSC)	Chr 18: 52.34 – 53.54 Mb	Chr 18: 71.26 – 72.35 Mb
PubMed search

2ED7, 2ED8, 2ED9, 2EDB, 2EDD, 2EDE, 3AU4, 4URT

1630

13176

ENSG00000187323

ENSMUSG00000060534

P43146

P70211

NM_005215

NM_007831

NP_005206

NP_031857.2
NP_031857

Deleted in Colorectal Carcinoma, also known as DCC, is a protein which in humans is encoded by the DCC gene. DCC has long been implicated in colorectal cancer. While the official, full name of this gene is Deleted in Colorectal Carcinoma, it is almost universally called Deleted in Colorectal Cancer. The protein product of DCC is a single transmembrane receptor also known as DCC, and it has the same interchangeable name.

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