Delayed potassium rectifier current

KCNQ1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3BJ4, 3HFC, 3HFE, 4UMO, 4V0C
Identifiers
Aliases	KCNQ1, ATFB1, ATFB3, JLNS1, KCNA8, KCNA9, KVLQT1, Kv1.9, Kv7.1, LQT, LQT1, RWS, SQT2, WRS, potassium voltage-gated channel subfamily Q member 1
External IDs	OMIM: 607542 MGI: 108083 HomoloGene: 85014 GeneCards: KCNQ1
Genetically Related Diseases
type 2 diabetes mellitus
Targeted by Drug
mefenamic acid, niflumic acid
Gene ontology Molecular function • voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization • scaffold protein binding • protein kinase A regulatory subunit binding • calmodulin binding • ion channel activity • voltage-gated potassium channel activity • ion channel binding • outward rectifier potassium channel activity • delayed rectifier potassium channel activity • potassium channel activity • protein binding • phosphatidylinositol-4,5-bisphosphate binding • protein kinase A catalytic subunit binding • voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization • protein phosphatase 1 binding • voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization • voltage-gated ion channel activity Cellular component • integral component of membrane • cytoplasmic vesicle • endosome • cytoplasmic vesicle membrane • voltage-gated potassium channel complex • membrane • lysosome • endoplasmic reticulum • membrane raft • basolateral plasma membrane • plasma membrane • ion channel complex • cytoplasm • late endosome • early endosome Biological process • regulation of ventricular cardiac muscle cell membrane repolarization • negative regulation of delayed rectifier potassium channel activity • intestinal absorption • regulation of atrial cardiac muscle cell membrane repolarization • positive regulation of cardiac muscle contraction • cellular response to epinephrine stimulus • positive regulation of potassium ion transmembrane transport • renal absorption • negative regulation of voltage-gated potassium channel activity • inner ear development • cardiac muscle contraction • regulation of gene expression by genetic imprinting • cellular response to drug • sensory perception of sound • atrial cardiac muscle cell action potential • potassium ion export • regulation of heart rate by cardiac conduction • cellular response to cAMP • transport • cardiovascular system development • regulation of gastric acid secretion • transmembrane transport • ventricular cardiac muscle cell action potential • regulation of ion transmembrane transport • gene silencing • regulation of membrane repolarization • cardiac conduction • ion transport • potassium ion export across plasma membrane • positive regulation of heart rate • potassium ion transmembrane transport • membrane repolarization during cardiac muscle cell action potential • potassium ion transport • regulation of heart contraction • membrane repolarization • membrane repolarization during action potential • membrane repolarization during ventricular cardiac muscle cell action potential • membrane repolarization during atrial cardiac muscle cell action potential Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3784	16535
Ensembl	n/a	ENSMUSG00000009545
UniProt	P51787	P97414
RefSeq (mRNA)	NM_181798 NM_000218 NM_181797	NM_008434
RefSeq (protein)	NP_000209 NP_861463	NP_032460.2 NP_032460
Location (UCSC)	Chr 11: 2.44 – 2.85 Mb	Chr 7: 143.11 – 143.43 Mb
PubMed search

3BJ4, 3HFC, 3HFE, 4UMO, 4V0C

3784

16535

n/a

ENSMUSG00000009545

P51787

P97414

NM_181798
NM_000218
NM_181797

NM_008434

NP_000209
NP_861463

NP_032460.2
NP_032460

K_v7.1 (KvLQT1) is a potassium channel protein whose primary subunit in humans is encoded by the KCNQ1 gene. K_v7.1 is a voltage-gated potassium channel present in the cell membranes of cardiac tissue and in inner ear neurons among other tissues. In the cardiac cells, K_v7.1 mediates the I_Ks (or slow delayed rectifying K⁺) current that contributes to the repolarization of the cell, terminating the cardiac action potential and thereby the heart's contraction.

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