The Damascus affair of 1840 refers to the arrest of thirteen notable members of the Jewish community of Damascus who were accused of murdering a Christian monk for ritual purposes. The anti-semitic blood libel resulted in the accused being imprisoned and tortured by the Ottoman authorities and the populace attacking and pillaging a local synagogue. The affair drew widespread international attention which resulted in negotiations conducted in Alexandria from August 4 till August 28. The aftermath secured the unconditional release and recognition of innocence for the nine prisoners remaining alive and the issuing of a firman (edict) intended to halt the spread of blood libel accusations in the Ottoman Empire.
Under Ottoman Islamic rule, Christians and Jews were considered dhimmis—a class of non-Muslims possessing some limited rights under Muslim rule—and were allowed to practice their religious precepts. In return, they had to pay a tax, or jizya (a tax on non-Muslims similar to the imposition of Zakat - one of the Five Pillars of Islam, an obligatory wealth tax paid on certain assets which are not used productively for a period of a year), and recognize a lower legal and social status than that of Muslims. In 1831-32, Syria came under the rule of the Egyptians under Muhammad Ali. Muhammad Ali was said to have ruled at the sufferance of the European powers, led by France, and under his rule, the rights afforded Christians increased. This aroused a grudge among the Muslim majority toward its non-Muslim population. In the economic struggle between the Jews and the Christians, each side needed the backing and support of the Muslim majority, and tried to incite the Muslims against the opposite group. The Christians in Damascus complained about their cruel treatment by the Muslim judges. Fearing an additional wave of Muslim violence, following the return of Ottoman rule in Syria in 1840, they enlisted assistance of priests from Catholic orders, including the Franciscans (Observants) and the Capuchins. These priests reportedly brought the previously European blood libel myth with them.