DUSP5

DUSP5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2G6Z
Identifiers
Aliases	DUSP5, DUSP, HVH3, dual specificity phosphatase 5
External IDs	MGI: 2685183 HomoloGene: 3256 GeneCards: DUSP5
Gene ontology Molecular function • phosphoprotein phosphatase activity • protein binding • protein tyrosine phosphatase activity • MAP kinase tyrosine/serine/threonine phosphatase activity • hydrolase activity • phosphatase activity • protein tyrosine/serine/threonine phosphatase activity Cellular component • nucleoplasm • nucleus Biological process • inactivation of MAPK activity • protein dephosphorylation • MAPK cascade • activation of MAPK activity • endoderm formation • peptidyl-tyrosine dephosphorylation • dephosphorylation • peptidyl-threonine dephosphorylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1847	240672
Ensembl	ENSG00000138166	ENSMUSG00000034765
UniProt	Q16690	Q1HL35
RefSeq (mRNA)	NM_004419	NM_001085390
RefSeq (protein)	NP_004410	NP_001078859
Location (UCSC)	Chr 10: 110.5 – 110.51 Mb	Chr 19: 53.53 – 53.54 Mb
PubMed search

2G6Z

1847

240672

ENSG00000138166

ENSMUSG00000034765

Q16690

Q1HL35

NM_004419

NM_001085390

NP_004410

NP_001078859

Dual specificity protein phosphatase 5 is an enzyme that in humans is encoded by the DUSP5 gene.

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1/2, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus.

Model organisms have been used in the study of DUSP5 function. A conditional knockout mouse line called Dusp5^{tm1a(KOMP)Wtsi} was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping

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