DUSP4

DUSP4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3EZZ
Identifiers
Aliases	DUSP4, HVH2, MKP-2, MKP2, TYP, dual specificity phosphatase 4
External IDs	MGI: 2442191 HomoloGene: 1065 GeneCards: DUSP4
Gene ontology Molecular function • phosphoprotein phosphatase activity • MAP kinase tyrosine/serine/threonine phosphatase activity • hydrolase activity • protein tyrosine/serine/threonine phosphatase activity • protein tyrosine/threonine phosphatase activity • phosphatase activity • protein tyrosine phosphatase activity • MAP kinase threonine phosphatase activity Cellular component • nucleoplasm • nucleus Biological process • endoderm formation • protein dephosphorylation • inactivation of MAPK activity • peptidyl-threonine dephosphorylation • dephosphorylation • peptidyl-tyrosine dephosphorylation • negative regulation of ERK1 and ERK2 cascade Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1846	319520
Ensembl	ENSG00000120875	ENSMUSG00000031530
UniProt	Q13115	Q8BFV3
RefSeq (mRNA)	NM_001394 NM_057158	NM_176933
RefSeq (protein)	NP_001385 NP_476499	NP_795907.1 NP_795907
Location (UCSC)	Chr 8: 29.33 – 29.35 Mb	Chr 8: 34.81 – 34.82 Mb
PubMed search

3EZZ

1846

319520

ENSG00000120875

ENSMUSG00000031530

Q13115

Q8BFV3

NM_001394
NM_057158

NM_176933

NP_001385
NP_476499

NP_795907.1
NP_795907

Dual specificity protein phosphatase 4 is an enzyme that in humans is encoded by the DUSP4 gene.

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.

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