DUSP2

DUSP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1M3G
Identifiers
Aliases	DUSP2, PAC-1, PAC1, dual specificity phosphatase 2
External IDs	MGI: 101911 HomoloGene: 3255 GeneCards: DUSP2
Gene ontology Molecular function • protein tyrosine phosphatase activity • phosphatase activity • MAP kinase tyrosine/serine/threonine phosphatase activity • protein tyrosine/threonine phosphatase activity • protein binding • phosphoprotein phosphatase activity • hydrolase activity • protein tyrosine/serine/threonine phosphatase activity • mitogen-activated protein kinase binding Cellular component • nucleus • nuclear membrane Biological process • inactivation of MAPK activity • protein dephosphorylation • endoderm formation • dephosphorylation • peptidyl-tyrosine dephosphorylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1844	13537
Ensembl	ENSG00000158050	ENSMUSG00000027368
UniProt	Q05923	Q05922
RefSeq (mRNA)	NM_004418	NM_010090
RefSeq (protein)	NP_004409	NP_034220
Location (UCSC)	Chr 2: 96.14 – 96.15 Mb	Chr 2: 127.34 – 127.34 Mb
PubMed search

1M3G

1844

13537

ENSG00000158050

ENSMUSG00000027368

Q05923

Q05922

NM_004418

NM_010090

NP_004409

NP_034220

Dual specificity protein phosphatase 2 is an enzyme that in humans is encoded by the DUSP2 gene.

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus.

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