DUSP10

DUSP10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZZW, 2OUC, 2OUD, 3TG1
Identifiers
Aliases	DUSP10, MKP-5, MKP5, dual specificity phosphatase 10
External IDs	MGI: 1927070 HomoloGene: 5215 GeneCards: DUSP10
Gene ontology Molecular function • phosphoprotein phosphatase activity • phosphatase activity • MAP kinase phosphatase activity • protein tyrosine phosphatase activity • MAP kinase tyrosine/serine/threonine phosphatase activity • hydrolase activity • protein tyrosine/serine/threonine phosphatase activity Cellular component • cytoplasm • Golgi apparatus • nucleoplasm • nucleus • cytosol • nuclear speck Biological process • regulation of innate immune response • inactivation of MAPK activity • response to stress • regulation of adaptive immune response • protein dephosphorylation • oligodendrocyte differentiation • negative regulation of respiratory burst involved in inflammatory response • response to organic substance • negative regulation of JNK cascade • JNK cascade • response to lipopolysaccharide • negative regulation of oligodendrocyte differentiation • negative regulation of protein kinase activity by regulation of protein phosphorylation • negative regulation of stress-activated MAPK cascade • regulation of brown fat cell differentiation • peptidyl-tyrosine dephosphorylation • negative regulation of JUN kinase activity • dephosphorylation • positive regulation of regulatory T cell differentiation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11221	63953
Ensembl	ENSG00000143507	ENSMUSG00000039384
UniProt	Q9Y6W6	Q9ESS0
RefSeq (mRNA)	NM_007207 NM_144728 NM_144729	NM_022019
RefSeq (protein)	NP_009138	NP_071302.2 NP_071302
Location (UCSC)	Chr 1: 221.7 – 221.74 Mb	Chr 1: 184.01 – 184.08 Mb
PubMed search

1ZZW, 2OUC, 2OUD, 3TG1

11221

63953

ENSG00000143507

ENSMUSG00000039384

Q9Y6W6

Q9ESS0

NM_007207
NM_144728
NM_144729

NM_022019

NP_009138

NP_071302.2
NP_071302

Dual specificity protein phosphatase 10 is an enzyme that in humans is encoded by the DUSP10 gene.

Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene.

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