DSPP

DSPP
Identifiers
Aliases	DSPP, DFNA39, DGI1, DMP3, DPP, DSP, DTDP2, Dentin sialophosphoprotein
External IDs	GeneCards: DSPP
Gene ontology Molecular function • calcium ion binding • extracellular matrix structural constituent • collagen binding Cellular component • cytoplasm • extracellular region • proteinaceous extracellular matrix Biological process • multicellular organism development • skeletal system development • biomineral tissue development • extracellular matrix organization • ossification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1834	n/a
Ensembl	ENSG00000152591	n/a
UniProt	Q9NZW4	n/a
RefSeq (mRNA)	NM_014208	n/a
RefSeq (protein)	NP_055023	n/a
Location (UCSC)	Chr 4: 87.61 – 87.62 Mb	n/a
PubMed search		n/a

1834

n/a

ENSG00000152591

n/a

Q9NZW4

n/a

NM_014208

n/a

NP_055023

n/a

Dentin sialophosphoprotein, also known as DSPP, is a human gene that encodes for a protein of the same name.

This gene encodes two principal proteins of the dentin extracellular matrix of the tooth. The preproprotein is secreted by odontoblasts and cleaved into dentin sialoprotein and dentin phosphoprotein. Dentin phosphoprotein is thought to be involved in the biomineralization process of dentin. Mutations in this gene have been associated with dentinogenesis imperfecta-1; in some individuals, dentinogenesis imperfecta occurs in combination with an autosomal dominant form of deafness. Allelic differences due to repeat polymorphisms have been found for this gene.

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