DSG2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2YQG, 5ERD, 5J5J

Identifiers

DSG2, ARVC10, ARVD10, CDHF5, CMD1BB, HDGC, desmoglein 2

External IDs

Gene ontology
Molecular function	• calcium ion binding • metal ion binding • cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication • cell adhesion molecule binding
Cellular component	• integral component of membrane • lateral plasma membrane • membrane • intercalated disc • cell-cell junction • plasma membrane • desmosome • cell surface • cell junction • apical plasma membrane • extracellular exosome • cornified envelope
Biological process	• desmosome organization • maternal process involved in female pregnancy • response to progesterone • bundle of His cell-Purkinje myocyte adhesion involved in cell communication • cell adhesion • Purkinje myocyte development • regulation of heart rate by cardiac conduction • regulation of ventricular cardiac muscle cell action potential • homophilic cell adhesion via plasma membrane adhesion molecules • keratinization • cornification
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


1829


13511


ENSG00000046604


ENSMUSG00000044393


Q14126


O55111

RefSeq (mRNA)


NM_001943


NM_007883

RefSeq (protein)


NP_001934


NP_031909

Location (UCSC)

PubMed search

Desmoglein-2 is a protein that in humans is encoded by the DSG2 gene. Desmoglein-2 is highly expressed in epithelial cells and cardiomyocytes. Desmoglein-2 is localized to desmosome structures at regions of cell-cell contact and functions to structurally adhere adjacent cells together. In cardiac muscle, these regions are specialized regions known as intercalated discs. Mutations in desmoglein-2 have been associated with arrhythmogenic right ventricular cardiomyopathy and familial dilated cardiomyopathy.